| http://purl.uniprot.org/citations/28537559 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28537559 | http://www.w3.org/2000/01/rdf-schema#comment | "Embryonic stem cells co-express Oct4 and Oct1, a related protein with similar DNA-binding specificity. To study the role of Oct1 in ESC pluripotency and transcriptional control, we constructed germline and inducible-conditional Oct1-deficient ESC lines. ESCs lacking Oct1 show normal appearance, self-renewal and growth but manifest defects upon differentiation. They fail to form beating cardiomyocytes, generate neurons poorly, form small, poorly differentiated teratomas, and cannot generate chimeric mice. Upon RA-mediated differentiation, Oct1-deficient cells induce lineage-appropriate developmentally poised genes poorly while lineage-inappropriate genes, including extra-embryonic genes, are aberrantly expressed. In ESCs, Oct1 co-occupies a specific set of targets with Oct4, but does not occupy differentially expressed developmental targets. Instead, Oct1 occupies these targets as cells differentiate and Oct4 declines. These results identify a dynamic interplay between Oct1 and Oct4, in particular during the critical window immediately after loss of pluripotency when cells make the earliest developmental fate decisions."xsd:string |
| http://purl.uniprot.org/citations/28537559 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.20937"xsd:string |
| http://purl.uniprot.org/citations/28537559 | http://purl.uniprot.org/core/author | "Kang J."xsd:string |
| http://purl.uniprot.org/citations/28537559 | http://purl.uniprot.org/core/author | "Regev A."xsd:string |
| http://purl.uniprot.org/citations/28537559 | http://purl.uniprot.org/core/author | "Shen Z."xsd:string |
| http://purl.uniprot.org/citations/28537559 | http://purl.uniprot.org/core/author | "Shakya A."xsd:string |
| http://purl.uniprot.org/citations/28537559 | http://purl.uniprot.org/core/author | "Tantin D."xsd:string |
| http://purl.uniprot.org/citations/28537559 | http://purl.uniprot.org/core/author | "Jarboe E.A."xsd:string |
| http://purl.uniprot.org/citations/28537559 | http://purl.uniprot.org/core/author | "Tabaka M."xsd:string |
| http://purl.uniprot.org/citations/28537559 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28537559 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28537559 | http://purl.uniprot.org/core/pages | "e20937"xsd:string |
| http://purl.uniprot.org/citations/28537559 | http://purl.uniprot.org/core/title | "Enforcement of developmental lineage specificity by transcription factor Oct1."xsd:string |
| http://purl.uniprot.org/citations/28537559 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/28537559 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28537559 |
| http://purl.uniprot.org/citations/28537559 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28537559 |
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