| http://purl.uniprot.org/citations/28539390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28539390 | http://www.w3.org/2000/01/rdf-schema#comment | "BAT-controlled thermogenic activity is thought to be required for its capacity to prevent the development of insulin resistance. This hypothesis predicts that mediators of thermogenesis may help prevent diet-induced insulin resistance. We report that the mitochondrial fusion protein Mitofusin 2 (Mfn2) in BAT is essential for cold-stimulated thermogenesis, but promotes insulin resistance in obese mice. Mfn2 deletion in mice through Ucp1-cre (BAT-Mfn2-KO) causes BAT lipohypertrophy and cold intolerance. Surprisingly however, deletion of Mfn2 in mice fed a high fat diet (HFD) results in improved insulin sensitivity and resistance to obesity, while impaired cold-stimulated thermogenesis is maintained. Improvement in insulin sensitivity is associated with a gender-specific remodeling of BAT mitochondrial function. In females, BAT mitochondria increase their efficiency for ATP-synthesizing fat oxidation, whereas in BAT from males, complex I-driven respiration is decreased and glycolytic capacity is increased. Thus, BAT adaptation to obesity is regulated by Mfn2 and with BAT-Mfn2 absent, BAT contribution to prevention of insulin resistance is independent and inversely correlated to whole-body cold-stimulated thermogenesis."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.org/dc/terms/identifier | "doi:10.15252/embr.201643827"xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/author | "Liesa M."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/author | "Shirihai O.S."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/author | "Perissi V."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/author | "Su S."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/author | "Mahdaviani K."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/author | "Cardamone M."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/author | "Oliveira M.F."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/author | "Ritou E."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/author | "Corkey B.E."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/author | "Aprahamian T."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/author | "Stiles L."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/author | "Trudeau K.M."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/author | "Benador I.Y."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/author | "Enriquez-Zarralanga V."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/author | "Gharakhanian R.A."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/pages | "1123-1138"xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/title | "Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis."xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/28539390 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28539390 |
| http://purl.uniprot.org/citations/28539390 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28539390 |