| http://purl.uniprot.org/citations/28542810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28542810 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucocorticoid-induced TNFR-related protein (GITR) is constitutively expressed in T regulatory (Treg) cells and regulates their suppressive function. We identified two methylated CpG islands in the Gitr locus. Using a ChIP assay, we demonstrate that both DNMT1 and methyl-CpG-binding domain Protein 4 (MBD4) bind to the Gitr promoter. Moreover, knockdown of DNMT1 decreases the binding activity of MBD4. We observed much higher levels of both DNMT1 and MBD4 in human CD4+ CD25- conventional T (Tconv) cells. Moreover, co-overexpression of DNMT1 and MBD4 in Treg cells significantly inhibits GITR expression and impairs their suppressive activity. Our results reveal a novel molecular mechanism by which MBD4 inhibits GITR expression in a DNMT1-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.org/dc/terms/identifier | "doi:10.1002/1873-3468.12690"xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/author | "Gao Y."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/author | "Luo X."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/author | "Lin F."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/author | "Zhang P."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/author | "Zhao B."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/author | "Yuan X."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/author | "Wu K."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/author | "Zhu F."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/author | "Liang R."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/author | "Tsun A."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/pages | "1929-1939"xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/title | "DNMT1 cooperates with MBD4 to inhibit the expression of Glucocorticoid-induced TNFR-related protein in human T cells."xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://purl.uniprot.org/core/volume | "591"xsd:string |
| http://purl.uniprot.org/citations/28542810 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28542810 |
| http://purl.uniprot.org/citations/28542810 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28542810 |