| http://purl.uniprot.org/citations/28546549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28546549 | http://www.w3.org/2000/01/rdf-schema#comment | "Production of IFN-γ contributes to host defense against Mycobacterium tuberculosis (Mtb) infection. We previously demonstrated that Signaling lymphocytic activation molecule-associated protein (SAP) expression on cells from tuberculosis (TB) patients was inversely correlated with IFN-γ production. Here we first investigated the role of NK, T- and B-cell antigen (NTB-A)/SAP pathway in the regulation of Th1 response against Mtb. Upon antigen stimulation, NTB-A phosphorylation rapidly increases and afterwards modulates IFN-γ and IL-17 secretion. To sustain a healthy immune system, controlled expansion and contraction of lymphocytes, both during and after an adaptive immune response, is essential. Besides, restimulation-induced cell death (RICD) results in an essential homeostatic mechanism for precluding excess T-cell accumulation and associated immunopathology during the course of certain infections. Accordingly, we found that the NTB-A/SAP pathway was required for RICD during active tuberculosis. In low responder (LR) TB patients, impaired RICD was associated with diminished FASL levels, IL-2 production and CD25high expression after cell-restimulation. Interestingly, we next observed that SAP mediated the recruitment of the Src-related kinase FYNT, only in T cells from LR TB patients that were resistant to RICD. Together, we showed that the NTB-A/SAP pathway regulates T-cell activation and RICD during human TB. Moreover, the NTB-A/SAP/FYNT axis promotes polarization to an unfavorable Th2-phenotype."xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.org/dc/terms/identifier | "doi:10.1038/icb.2017.42"xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/author | "Garcia V.E."xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/author | "Pena D."xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/author | "Malbran A."xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/author | "Musella R.M."xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/author | "Pasquinelli V."xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/author | "Rovetta A.I."xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/author | "Palmero D.J."xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/author | "Hernandez Del Pino R.E."xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/author | "Pellegrini J.M."xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/author | "Rolandelli A."xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/author | "Alvarez G.I."xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/name | "Immunol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/pages | "716-728"xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/title | "Restimulation-induced T-cell death through NTB-A/SAP signaling pathway is impaired in tuberculosis patients with depressed immune responses."xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/28546549 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28546549 |
| http://purl.uniprot.org/citations/28546549 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28546549 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TLH8-mappedCitation-28546549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28546549 |
| http://purl.uniprot.org/uniprot/#_B4E1U5-mappedCitation-28546549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28546549 |
| http://purl.uniprot.org/uniprot/#_B7Z6A7-mappedCitation-28546549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28546549 |
| http://purl.uniprot.org/uniprot/#_K7YQB3-mappedCitation-28546549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28546549 |