| http://purl.uniprot.org/citations/28550204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28550204 | http://www.w3.org/2000/01/rdf-schema#comment | "In NOD mice, CD11c+ cells increase greatly with islet inflammation and contribute to autoimmune destruction of pancreatic β cells. In this study, we investigated their origin and mechanism of recruitment. CD11c+ cells in inflamed islets resembled classical dendritic cells based on their transcriptional profile. However, the majority of these cells were not from the Zbtb46-dependent dendritic-cell lineage. Instead, monocyte precursors could give rise to CD11c+ cells in inflamed islets. Chemokines Ccl5 and Ccl8 were persistently elevated in inflamed islets and the influx of CD11c+ cells was partially dependent on their receptor Ccr5. Treatment with islet Ag-specific regulatory T cells led to a marked decrease of Ccl5 and Ccl8, and a reduction of monocyte recruitment. These results implicate a monocytic origin of CD11c+ cells in inflamed islets and suggest that therapeutic regulatory T cells directly or indirectly regulate their influx by altering the chemotactic milieu in the islets."xsd:string |
| http://purl.uniprot.org/citations/28550204 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1601062"xsd:string |
| http://purl.uniprot.org/citations/28550204 | http://purl.uniprot.org/core/author | "Nguyen V."xsd:string |
| http://purl.uniprot.org/citations/28550204 | http://purl.uniprot.org/core/author | "Tang Q."xsd:string |
| http://purl.uniprot.org/citations/28550204 | http://purl.uniprot.org/core/author | "Murphy K.M."xsd:string |
| http://purl.uniprot.org/citations/28550204 | http://purl.uniprot.org/core/author | "Satpathy A.T."xsd:string |
| http://purl.uniprot.org/citations/28550204 | http://purl.uniprot.org/core/author | "Spence A."xsd:string |
| http://purl.uniprot.org/citations/28550204 | http://purl.uniprot.org/core/author | "Klementowicz J.E."xsd:string |
| http://purl.uniprot.org/citations/28550204 | http://purl.uniprot.org/core/author | "Mahne A.E."xsd:string |
| http://purl.uniprot.org/citations/28550204 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28550204 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/28550204 | http://purl.uniprot.org/core/pages | "27-32"xsd:string |
| http://purl.uniprot.org/citations/28550204 | http://purl.uniprot.org/core/title | "Cutting Edge: Origins, Recruitment, and Regulation of CD11c+ Cells in Inflamed Islets of Autoimmune Diabetes Mice."xsd:string |
| http://purl.uniprot.org/citations/28550204 | http://purl.uniprot.org/core/volume | "199"xsd:string |
| http://purl.uniprot.org/citations/28550204 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28550204 |
| http://purl.uniprot.org/citations/28550204 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28550204 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SS26-mappedCitation-28550204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28550204 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNJ3-mappedCitation-28550204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28550204 |
| http://purl.uniprot.org/uniprot/#_E0CZ94-mappedCitation-28550204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28550204 |
| http://purl.uniprot.org/uniprot/#_E9Q351-mappedCitation-28550204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28550204 |
| http://purl.uniprot.org/uniprot/#_E9Q3E5-mappedCitation-28550204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28550204 |
| http://purl.uniprot.org/uniprot/#_Q149U7-mappedCitation-28550204 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28550204 |
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