| http://purl.uniprot.org/citations/28552577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28552577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28552577 | http://www.w3.org/2000/01/rdf-schema#comment | "Microtubule plus-end tracking proteins (+TIPs) are involved in virtually all microtubule-based processes. End-binding (EB) proteins are considered master regulators of +TIP interaction networks, since they autonomously track growing microtubule ends and recruit a plethora of proteins to this location. Two major EB-interacting elements have been described: CAP-Gly domains and linear SxIP sequence motifs. Here, we identified LxxPTPh as a third EB-binding motif that enables major +TIPs to interact with EBs at microtubule ends. In contrast to EB-SxIP and EB-CAP-Gly, the EB-LxxPTPh binding mode does not depend on the C-terminal tail region of EB. Our study reveals that +TIPs developed additional strategies besides CAP-Gly and SxIP to target EBs at growing microtubule ends. They further provide a unique basis to discover novel +TIPs, and to dissect the role of key interaction nodes and their differential regulation for hierarchical +TIP network organization and function in eukaryotic organisms."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2017.04.010"xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2017.04.010"xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Grigoriev I."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Grigoriev I."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Kumar A."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Kumar A."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Prota A.E."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Prota A.E."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Rai A."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Rai A."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Kammerer R.A."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Kammerer R.A."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Steinmetz M.O."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Steinmetz M.O."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Jaussi R."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Jaussi R."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Akhmanova A."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Akhmanova A."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Volkmer R."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Volkmer R."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Manatschal C."xsd:string |
| http://purl.uniprot.org/citations/28552577 | http://purl.uniprot.org/core/author | "Manatschal C."xsd:string |