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http://purl.uniprot.org/citations/28552862http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28552862http://www.w3.org/2000/01/rdf-schema#comment"

Background

Concentrations of the anti-angiogenic factor soluble fms-like tyrosine kinase-1 (sFlt-1) are altered in peripartum cardiomyopathy (PPCM). In this study we investigated changes in the angiogenesis balance in PPCM.Methods and Results:Plasma concentrations of sFlt-1 and the pro-angiogenic placenta growth factor (PlGF) were determined in patients with PPCM during the post-partum phase (n=83), in healthy women at delivery (n=30), and in patients with acute heart failure (AHF; n=65). Women with cardiac failure prepartum or associated with any form of hypertension, including pre-eclampsia, were excluded. Compared with non-pregnant women, in women with AHF and PPCM, median PlGF concentrations were greater (19 [IQR 16-22] and 98 [IQR 78-126] ng/mL, respectively; P<0.001) and the sFlt-1/PlGF ratio was lower (9.8 [6.6-11.3] and 1.2 [0.9-2.8], respectively; P<0.001). The sFlt-1/PlGF ratio was lower in PPCM than in normal deliveries (1.2 [0.9-2.8] vs. 94.8 [68.8-194.1], respectively; P<0.0001). The area under the curve for PlGF (cut-off value: 50ng/mL) and/or the sFlt-1/PlGF ratio (cut-off value: 4) to distinguish PPCM from either normal delivery or AHF was >0.94. Median plasma concentrations of the anti-angiogenic factor relaxin-2 were lower in PPCM and AHF (0.3 [IQR 0.3-1.7] and 0.3 [IQR 0.3-1] ng/mL, respectively) compared with normal deliveries (1,807 [IQR 1,101-4,050] ng/mL; P<0.001).

Conclusions

Plasma of PPCM patients shows imbalanced angiogenesis. High PlGF and/or low sFlt-1/PlGF may be used to diagnose PPCM."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.org/dc/terms/identifier"doi:10.1253/circj.cj-16-1193"xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Legrand M."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Collet C."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Launay J.M."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Manivet P."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Samuel J.L."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Deschamps L."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Seronde M.F."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Sliwa K."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Mebazaa A."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Solal A.C."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Fazal L."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Gayat E."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Laribi S."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Sadoune M."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Arrigo M."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Akrout N."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Anumba D.O.C."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Bouadma L."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Motiejunaite J."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Sarb J."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/author"Tibazarwa K."xsd:string
http://purl.uniprot.org/citations/28552862http://purl.uniprot.org/core/date"2017"xsd:gYear
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