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Purpose

Gestational diabetes mellitus (GDM) may share similar mechanisms with type 2 diabetes and obesity. In the current study, we aimed to verify twenty genes reported to be associated with type 2 diabetes and obesity in the Chinese GDM population.

Methods

Pregnant women aged 20-49 years at 24-28 gestational weeks were recruited and 556 cases and 445 controls were enrolled in the study. The genotyping of single nucleotide polymorphisms (SNPs) was performed on peripheral blood samples.

Results

We discovered that GDM was associated with rs945508 (OR = 1.368, 95% CI = 1.080-1.732, p = .009), rs10804591 (OR = 1.446, 95% CI = 1.192-1.754, p < .001), rs10245353 (OR = 1.204, 95% CI = 1.006-1.441, p = .043) and rs1552224 (OR = 1.451, 95% CI = 1.071-1.964, p = .016).

Conclusions

We found that four SNPs associated with type 2 diabetes and obesity may also increase the risk of developing GDM in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM."xsd:string
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http://purl.uniprot.org/citations/28554271http://purl.uniprot.org/core/author"Wang Y."xsd:string
http://purl.uniprot.org/citations/28554271http://purl.uniprot.org/core/author"Yang H."xsd:string
http://purl.uniprot.org/citations/28554271http://purl.uniprot.org/core/author"Wang H."xsd:string
http://purl.uniprot.org/citations/28554271http://purl.uniprot.org/core/author"Yan J."xsd:string
http://purl.uniprot.org/citations/28554271http://purl.uniprot.org/core/author"Su R."xsd:string
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http://purl.uniprot.org/citations/28554271http://purl.uniprot.org/core/name"J Matern Fetal Neonatal Med"xsd:string
http://purl.uniprot.org/citations/28554271http://purl.uniprot.org/core/pages"2115-2121"xsd:string
http://purl.uniprot.org/citations/28554271http://purl.uniprot.org/core/title"Genetic variants and clinical relevance associated with gestational diabetes mellitus in Chinese women: a case-control study."xsd:string
http://purl.uniprot.org/citations/28554271http://purl.uniprot.org/core/volume"31"xsd:string
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