| http://purl.uniprot.org/citations/28554770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28554770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28554770 | http://www.w3.org/2000/01/rdf-schema#comment | "Current models imply that the evolutionarily conserved, actin-binding Ezrin-Radixin-Moesin (ERM) proteins perform their activities at the plasma membrane by anchoring membrane proteins to the cortical actin network. Here we show that beside its cytoplasmic functions, the single ERM protein of Drosophila, Moesin, has a novel role in the nucleus. The activation of transcription by heat shock or hormonal treatment increases the amount of nuclear Moesin, indicating biological function for the protein in the nucleus. The distribution of Moesin in the nucleus suggests a function in transcription and the depletion of mRNA export factors Nup98 or its interacting partner, Rae1, leads to the nuclear accumulation of Moesin, suggesting that the nuclear function of the protein is linked to mRNA export. Moesin localizes to mRNP particles through the interaction with the mRNA export factor PCID2 and knock down of Moesin leads to the accumulation of mRNA in the nucleus. Based on our results we propose that, beyond its well-known, manifold functions in the cytoplasm, the ERM protein of Drosophila is a new, functional component of the nucleus where it participates in mRNA export."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2017.05.020"xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2017.05.020"xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Dopie J."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Dopie J."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Vartiainen M.K."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Vartiainen M.K."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Vilmos P."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Vilmos P."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Erdelyi M."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Erdelyi M."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Bajusz C."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Bajusz C."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Borsos B.N."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Borsos B.N."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Jankovics F."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Jankovics F."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Kristo I."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Kristo I."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Pankotai T."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/author | "Pankotai T."xsd:string |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28554770 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |