| http://purl.uniprot.org/citations/28555620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28555620 | http://www.w3.org/2000/01/rdf-schema#comment | "Inflammation and thrombosis occur together in many diseases. The leukocyte integrin Mac-1 (also known as integrin αMβ2, or CD11b/CD18) is crucial for leukocyte recruitment to the endothelium, and Mac-1 engagement of platelet GPIbα is required for injury responses in diverse disease models. However, the role of Mac-1 in thrombosis is undefined. Here we report that mice with Mac-1 deficiency (Mac-1-/-) or mutation of the Mac-1-binding site for GPIbα have delayed thrombosis after carotid artery and cremaster microvascular injury without affecting parameters of haemostasis. Adoptive wild-type leukocyte transfer rescues the thrombosis defect in Mac-1-/- mice, and Mac-1-dependent regulation of the transcription factor Foxp1 contributes to thrombosis as evidenced by delayed thrombosis in mice with monocyte-/macrophage-specific overexpression of Foxp1. Antibody and small-molecule targeting of Mac-1:GPIbα inhibits thrombosis. Our data identify a new pathway of thrombosis involving leukocyte Mac-1 and platelet GPIbα, and suggest that targeting this interaction has anti-thrombotic therapeutic potential with reduced bleeding risk."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms15559"xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/author | "Gao H."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/author | "Qin J."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/author | "Shi C."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/author | "Zhu L."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/author | "Pavlovsky A."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/author | "Lopez J."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/author | "Plow E."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/author | "Simon D.I."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/author | "Munday A.D."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/author | "Bledzka K."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/author | "Ustinov V."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/author | "A Soloviev D."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/author | "Erhardt P.W."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/pages | "15559"xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/title | "Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbalpha."xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/28555620 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28555620 |
| http://purl.uniprot.org/citations/28555620 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28555620 |
| http://purl.uniprot.org/uniprot/#_E9Q604-mappedCitation-28555620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28555620 |