| http://purl.uniprot.org/citations/28557996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28557996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28557996 | http://www.w3.org/2000/01/rdf-schema#comment | "Dietary restriction (DR) and reduced insulin growth factor (IGF) signaling extend lifespan in Caenorhabditis elegans and other eukaryotic organisms. Autophagy, an evolutionarily conserved lysosomal degradation pathway, has emerged as a central pathway regulated by various longevity signals including DR and IGF signaling in promoting longevity in a variety of eukaryotic organisms. However, the mechanism remains unclear. Here we show that the autophagy protein ATG-18 acts cell non-autonomously in neuronal and intestinal tissues to maintain C. elegans wildtype lifespan and to respond to DR and IGF-mediated longevity signaling. Moreover, ATG-18 activity in chemosensory neurons that are involved in food detection sufficiently mediates the effect of these longevity pathways. Additionally, ATG-18-mediated cell non-autonomous signaling depends on the release of neurotransmitters and neuropeptides. Interestingly, our data suggest that neuronal and intestinal ATG-18 acts in parallel and converges on unidentified neurons that secrete neuropeptides to regulate C. elegans lifespan through the transcription factor DAF-16/FOXO in response to reduced IGF signaling."xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1006764"xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1006764"xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/author | "Jia K."xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/author | "Jia K."xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/author | "Kaul T."xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/author | "Kaul T."xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/author | "Minnerly J."xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/author | "Minnerly J."xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/author | "Parker T."xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/author | "Parker T."xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/pages | "E1006764"xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/pages | "E1006764"xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/title | "The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan."xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/title | "The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan."xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/28557996 | http://purl.uniprot.org/core/volume | "13"xsd:string |