| http://purl.uniprot.org/citations/28561026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28561026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28561026 | http://www.w3.org/2000/01/rdf-schema#comment | "The R2TP/Prefoldin-like (R2TP/PFDL) complex has emerged as a cochaperone complex involved in the assembly of a number of critical protein complexes including snoRNPs, nuclear RNA polymerases and PIKK-containing complexes. Here we report on the use of multiple target affinity purification coupled to mass spectrometry to identify two additional complexes that interact with R2TP/PFDL: the TSC1-TSC2 complex and the U5 small nuclear ribonucleoprotein (snRNP). The interaction between R2TP/PFDL and the U5 snRNP is mostly mediated by the previously uncharacterized factor ZNHIT2. A more general function for the zinc-finger HIT domain in binding RUVBL2 is exposed. Disruption of ZNHIT2 and RUVBL2 expression impacts the protein composition of the U5 snRNP suggesting a function for these proteins in promoting the assembly of the ribonucleoprotein. A possible implication of R2TP/PFDL as a major effector of stress-, energy- and nutrient-sensing pathways that regulate anabolic processes through the regulation of its chaperoning activity is discussed."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms15615"xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms15615"xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Chabot B."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Chabot B."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Durand M."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Durand M."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Hekmat O."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Hekmat O."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Cloutier P."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Cloutier P."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Coulombe B."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Coulombe B."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Faubert D."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Faubert D."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Bouchard A."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Bouchard A."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Poitras C."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Poitras C."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Fiola-Masson E."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/author | "Fiola-Masson E."xsd:string |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28561026 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |