| http://purl.uniprot.org/citations/28561736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28561736 | http://www.w3.org/2000/01/rdf-schema#comment | "Here, we describe a novel method based on intronic MiMIC insertions described in Nagarkar-Jaiswal et al. (2015) to perform conditional gene inactivation in Drosophila. Mosaic analysis in Drosophila cannot be easily performed in post-mitotic cells. We therefore, therefore, developed Flip-Flop, a flippase-dependent in vivo cassette-inversion method that marks wild-type cells with the endogenous EGFP-tagged protein, whereas mutant cells are marked with mCherry upon inversion. We document the ease and usefulness of this strategy in differential tagging of wild-type and mutant cells in mosaics. We use this approach to phenotypically characterize the loss of SNF4Aγ, encoding the γ subunit of the AMP Kinase complex. The Flip-Flop method is efficient and reliable, and permits conditional gene inactivation based on both spatial and temporal cues, in a cell cycle-, and developmental stage-independent fashion, creating a platform for systematic screens of gene function in developing and adult flies with unprecedented detail."xsd:string |
| http://purl.uniprot.org/citations/28561736 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.26420"xsd:string |
| http://purl.uniprot.org/citations/28561736 | http://purl.uniprot.org/core/author | "Zuo Z."xsd:string |
| http://purl.uniprot.org/citations/28561736 | http://purl.uniprot.org/core/author | "Bellen H.J."xsd:string |
| http://purl.uniprot.org/citations/28561736 | http://purl.uniprot.org/core/author | "Nagarkar-Jaiswal S."xsd:string |
| http://purl.uniprot.org/citations/28561736 | http://purl.uniprot.org/core/author | "Manivannan S.N."xsd:string |
| http://purl.uniprot.org/citations/28561736 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28561736 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28561736 | http://purl.uniprot.org/core/pages | "e26420"xsd:string |
| http://purl.uniprot.org/citations/28561736 | http://purl.uniprot.org/core/title | "A cell cycle-independent, conditional gene inactivation strategy for differentially tagging wild-type and mutant cells."xsd:string |
| http://purl.uniprot.org/citations/28561736 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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