| http://purl.uniprot.org/citations/28566713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28566713 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of the endothelium by pro-inflammatory stimuli plays a key role in the pathogenesis of a multitude of vascular diseases. Angiogenesis is a crucial component of the vascular response associated with inflammatory signaling. The CD40/CD40 ligand dyad in endothelial cells (EC) has a central role in promoting vascular inflammatory response; however, the molecular mechanism underlying this component of inflammation and angiogenesis is not fully understood. Here we report a novel microRNA mediated suppression of endothelial CD40 expression. We found that CD40 is closely regulated by miR-424 and miR-503, which directly target its 3' untranslated region. Pro-inflammatory stimuli led to increased endothelial CD40 expression, at least in part due to decreased miR-424 and miR-503 expression. In addition, miR-424 and miR-503 reduced LPS induced EC sprouting, migration and tube formation. Moreover, we found that miR-424 and miR-503 expression is directly regulated by peroxisome proliferator-activated receptor gamma (PPARγ), whose endothelial expression and activity are decreased in response to inflammatory factors. Finally, we demonstrate that mice with endothelial-specific deletion of miR-322 (miR-424 ortholog) and miR-503 have augmented angiogenic response to LPS in a Matrigel plug assay. Overall, these studies identify a PPARγ-dependent miR-424/503-CD40 signaling axis that is critical for regulation of inflammation mediated angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/28566713 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-02852-4"xsd:string |
| http://purl.uniprot.org/citations/28566713 | http://purl.uniprot.org/core/author | "Kang H."xsd:string |
| http://purl.uniprot.org/citations/28566713 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/28566713 | http://purl.uniprot.org/core/author | "Lee A."xsd:string |
| http://purl.uniprot.org/citations/28566713 | http://purl.uniprot.org/core/author | "Park Y."xsd:string |
| http://purl.uniprot.org/citations/28566713 | http://purl.uniprot.org/core/author | "Choi J."xsd:string |
| http://purl.uniprot.org/citations/28566713 | http://purl.uniprot.org/core/author | "Chun H.J."xsd:string |
| http://purl.uniprot.org/citations/28566713 | http://purl.uniprot.org/core/author | "Papangeli I."xsd:string |
| http://purl.uniprot.org/citations/28566713 | http://purl.uniprot.org/core/author | "Jeong H.N."xsd:string |
| http://purl.uniprot.org/citations/28566713 | http://purl.uniprot.org/core/author | "Jo H.N."xsd:string |
| http://purl.uniprot.org/citations/28566713 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28566713 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28566713 | http://purl.uniprot.org/core/pages | "2528"xsd:string |
| http://purl.uniprot.org/citations/28566713 | http://purl.uniprot.org/core/title | "A PPARgamma-dependent miR-424/503-CD40 axis regulates inflammation mediated angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/28566713 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28566713 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28566713 |
| http://purl.uniprot.org/citations/28566713 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28566713 |
| http://purl.uniprot.org/uniprot/P37231#attribution-4B31528F8B94A78551DFEAF3261A7880 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28566713 |
| http://purl.uniprot.org/uniprot/P25942#attribution-A64D9072CA2217E5932395778E58E173 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28566713 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SV67-mappedCitation-28566713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28566713 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVF8-mappedCitation-28566713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28566713 |
| http://purl.uniprot.org/uniprot/#_A2A5L7-mappedCitation-28566713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28566713 |
| http://purl.uniprot.org/uniprot/#_A0N0C8-mappedCitation-28566713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28566713 |