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| http://purl.uniprot.org/citations/28567756 | http://www.w3.org/2000/01/rdf-schema#comment | "The capacity of the usual tests (chi-square and related tests) to detect gametic disequilibrium between allozyme loci in natural populations of Drosophila has been investigated. We analyzed a large collection of previously reported gametic samples from natural populations involving a variety of loosely linked allozyme loci located along the O chromosome of Drosophila subobscura and the second chromosome of D. melanogaster. It is found that the statistical power of the individual tests to detect the sample disequilibria between allozyme loci is remarkably low, being the average (over pairs of loci) of power estimates close to 0.20 in both species. Moreover, the average minimum disequilibrium (D'min ) that would be required to reject (90% probability) the hypothesis of gametic equilibrium is higher than 0.50 given the observed degree of polymorphism and sample sizes used. This means that statistically significant associations between allozyme loci would rarely be detected by single-sample tests even when much disequilibrium is present in natural populations of Drosophila. However, an alternative approach based on the analysis of disquilibrium for large sets of gametic samples, combining probabilities from single independent tests and assessing significance by a bootstrap procedure, reveals that most of the locus pairs within segment I and II of the O chromosome of D. subobscura and left arm of the second chromosome of D. melanogaster present significant nonrandom associations. Within these chromosomal sections, the observed average absolute value of disquilibrium (D') between loci is around 0.25 (under the more conservative estimation). Also, a positive relationship between the magnitude of disequilibrium and linkage was detected. These findings suggest that weak or moderate values of disequilibrium between loosely linked allozyme loci are more frequent in natural populations of Drosophila than is currently believed."xsd:string |
| http://purl.uniprot.org/citations/28567756 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1558-5646.1992.tb01177.x"xsd:string |
| http://purl.uniprot.org/citations/28567756 | http://purl.uniprot.org/core/author | "Alvarez G."xsd:string |
| http://purl.uniprot.org/citations/28567756 | http://purl.uniprot.org/core/author | "Zapata C."xsd:string |
| http://purl.uniprot.org/citations/28567756 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/28567756 | http://purl.uniprot.org/core/name | "Evolution"xsd:string |
| http://purl.uniprot.org/citations/28567756 | http://purl.uniprot.org/core/pages | "1900-1917"xsd:string |
| http://purl.uniprot.org/citations/28567756 | http://purl.uniprot.org/core/title | "THE DETECTION OF GAMETIC DISEQUILIBRIUM BETWEEN ALLOZYME LOCI IN NATURAL POPULATIONS OF DROSOPHILA."xsd:string |
| http://purl.uniprot.org/citations/28567756 | http://purl.uniprot.org/core/volume | "46"xsd:string |
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