| http://purl.uniprot.org/citations/28569745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28569745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28569745 | http://www.w3.org/2000/01/rdf-schema#comment | "Although recent evidence has pointed to the existence of small open reading frame (smORF)-encoded microproteins in mammals, their function remains to be determined. Skeletal muscle development requires fusion of mononuclear progenitors to form multinucleated myotubes, a critical but poorly understood process. Here we report the identification of Minion (microprotein inducer of fusion), a smORF encoding an essential skeletal muscle specific microprotein. Myogenic progenitors lacking Minion differentiate normally but fail to form syncytial myotubes, and Minion-deficient mice die perinatally and demonstrate a marked reduction in fused muscle fibres. The fusogenic activity of Minion is conserved in the human orthologue, and co-expression of Minion and the transmembrane protein Myomaker is sufficient to induce cellular fusion accompanied by rapid cytoskeletal rearrangement, even in non-muscle cells. These findings establish Minion as a novel microprotein required for muscle development, and define a two-component programme for the induction of mammalian cell fusion. Moreover, these data also significantly expand the known functions of smORF-encoded microproteins."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms15664"xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms15664"xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Romero A."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Romero A."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Vashisht A.A."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Vashisht A.A."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Durrant E."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Durrant E."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "O'Rourke J."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "O'Rourke J."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Sampath S.C."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Sampath S.C."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Schmedt C."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Schmedt C."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Miraglia L."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Miraglia L."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Moran R."xsd:string |
| http://purl.uniprot.org/citations/28569745 | http://purl.uniprot.org/core/author | "Moran R."xsd:string |