| http://purl.uniprot.org/citations/28570664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28570664 | http://www.w3.org/2000/01/rdf-schema#comment | "A recent study identified SCYL1 as one of the components of the oncogenic STP axis, which promotes triple-negative breast cancer by regulating degradation of the REST tumor suppressor. Contrary to the findings of that study, herein we show by using 3 distinct genetic approaches that SCYL1 does not regulate REST turnover. Specifically, REST protein levels and turnover were identical in Scyl1+/+ and Scyl1-/-mouse embryonic fibroblasts. Similarly, targeted inactivation of SCYL1 in Hek293T cells by using CRIPSR-Cas9 technology did not affect REST steady-state level and turnover. Furthermore, RNA interference-mediated depletion of SCYL1 in Hek293T or MDA-MB-231 cells did not alter REST steady-state level and turnover. Together, our findings indicate that SCYL1 does not contribute to REST turnover and thus do not support a previous study suggesting a role for SCYL1 in mediating REST degradation."xsd:string |
| http://purl.uniprot.org/citations/28570664 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0178680"xsd:string |
| http://purl.uniprot.org/citations/28570664 | http://purl.uniprot.org/core/author | "Pelletier S."xsd:string |
| http://purl.uniprot.org/citations/28570664 | http://purl.uniprot.org/core/author | "Gingras S."xsd:string |
| http://purl.uniprot.org/citations/28570664 | http://purl.uniprot.org/core/author | "Kuliyev E."xsd:string |
| http://purl.uniprot.org/citations/28570664 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28570664 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/28570664 | http://purl.uniprot.org/core/pages | "e0178680"xsd:string |
| http://purl.uniprot.org/citations/28570664 | http://purl.uniprot.org/core/title | "SCYL1 does not regulate REST expression and turnover."xsd:string |
| http://purl.uniprot.org/citations/28570664 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/28570664 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28570664 |
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