| http://purl.uniprot.org/citations/28574724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28574724 | http://www.w3.org/2000/01/rdf-schema#comment | "microRNAs (miRNAs) have been proved to be involved in many events of tumor development and progression, including cell proliferation, cell apoptosis, and cell cycle arrest. However, the potential role of miR-144-3p in pancreatic cancer (PC) remains elusive. In this study, we demonstrated that miR-144-3p was decreased in PC tissues and PANC-1 cells, whereas proline-rich protein 11 (PRR11) was remarkably increased. miR-144-3p mimics were discovered to inhibit cell proliferation by arresting cells at the S-phase of the cell cycle, and inducing cell apoptosis in PANC-1 cells. The effects of miR-144-3p on cell proliferation and cell apoptosis were reversed after treatment with the miR-144-3p inhibitor. Furthermore, a luciferase activity assay indicated that miR-144-3p directly targeted PRR11 3'-UTR. Moreover, transfection with miR-144-3p mimics inhibited the expression of PRR11. miR-144-3p mimics also upregulated the expression of p-JNK and p-p38, whereas they downregulated the expression of p-ERK. The effects of miR-144-3p on mitogen-activated protein kinase pathway proteins were reversed by the miR-144-3p inhibitor. PRR11 overexpression attenuated the effect of miR-144-3p mimics on cell apoptosis and cell cycle arrest. The expression of caspase-3 was decreased by enhanced PRR11. In summary, our findings indicated that miR-144-3p induced cell cycle arrest and apoptosis in PC by targeting PRR11. Therefore, the targeting of miR-144-3p could serve as a potential therapeutic strategy for the treatment of PC."xsd:string |
| http://purl.uniprot.org/citations/28574724 | http://purl.org/dc/terms/identifier | "doi:10.1089/dna.2017.3656"xsd:string |
| http://purl.uniprot.org/citations/28574724 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/28574724 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/28574724 | http://purl.uniprot.org/core/author | "Sun P."xsd:string |
| http://purl.uniprot.org/citations/28574724 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/28574724 | http://purl.uniprot.org/core/author | "Yue Z."xsd:string |
| http://purl.uniprot.org/citations/28574724 | http://purl.uniprot.org/core/author | "You K."xsd:string |
| http://purl.uniprot.org/citations/28574724 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28574724 | http://purl.uniprot.org/core/name | "DNA Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/28574724 | http://purl.uniprot.org/core/pages | "619-626"xsd:string |
| http://purl.uniprot.org/citations/28574724 | http://purl.uniprot.org/core/title | "miR-144-3p Induces Cell Cycle Arrest and Apoptosis in Pancreatic Cancer Cells by Targeting Proline-Rich Protein 11 Expression via the Mitogen-Activated Protein Kinase Signaling Pathway."xsd:string |
| http://purl.uniprot.org/citations/28574724 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/28574724 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28574724 |
| http://purl.uniprot.org/citations/28574724 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28574724 |
| http://purl.uniprot.org/uniprot/#_D2SNZ4-mappedCitation-28574724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28574724 |
| http://purl.uniprot.org/uniprot/#_Q96HE9-mappedCitation-28574724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28574724 |
| http://purl.uniprot.org/uniprot/D2SNZ4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28574724 |
| http://purl.uniprot.org/uniprot/Q96HE9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28574724 |