| http://purl.uniprot.org/citations/28575455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28575455 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundAdolescent intermittent ethanol exposure causes long-lasting alterations in brain epigenetic mechanisms. Melanocortin and neuropeptide Y signaling interact and are affected by ethanol exposure in the brain. Here, the persistent effects of adolescent intermittent ethanol on alpha-melanocyte stimulating hormone, melanocortin 4 receptor, and neuropeptide Y expression and their regulation by histone acetylation mechanisms were investigated in adulthood.MethodsMale rats were exposed to adolescent intermittent ethanol (2 g/kg, i.p.) or volume-matched adolescent intermittent saline from postnatal days 28 to 41 and allowed to grow to postnatal day 92. Anxiety-like behaviors were measured by the elevated plus-maze test. Brain regions from adult rats were used to examine changes in alpha-melanocyte stimulating hormone, melanocortin 4 receptor, and neuropeptide Y expression and the histone acetylation status of their promoters.ResultsAdolescent intermittent ethanol-exposed adult rats displayed anxiety-like behaviors and showed increased pro-opiomelanocortin mRNA levels in the hypothalamus and increased melanocortin 4 receptor mRNA levels in both the amygdala and hypothalamus compared with adolescent intermittent saline-exposed adult rats. The alpha-Melanocyte stimulating hormone and melanocortin 4 receptor protein levels were increased in the central and medial nucleus of the amygdala, paraventricular nucleus, and arcuate nucleus of the hypothalamus in adolescent intermittent ethanol-exposed compared with adolescent intermittent saline-exposed adult rats. Neuropeptide Y protein levels were decreased in the central and medial nucleus of the amygdala of adolescent intermittent ethanol-exposed compared with adolescent intermittent saline-exposed adult rats. Histone H3K9/14 acetylation was decreased in the neuropeptide Y promoter in the amygdala but increased in the melanocortin 4 receptor gene promoter in the amygdala and the melanocortin 4 receptor and pro-opiomelanocortin promoters in the hypothalamus of adolescent intermittent ethanol-exposed adult rats compared with controls.ConclusionsIncreased melanocortin and decreased neuropeptide Y activity due to changes in histone acetylation in emotional brain circuitry may play a role in adolescent intermittent ethanol-induced anxiety phenotypes in adulthood."xsd:string |
| http://purl.uniprot.org/citations/28575455 | http://purl.org/dc/terms/identifier | "doi:10.1093/ijnp/pyx041"xsd:string |
| http://purl.uniprot.org/citations/28575455 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/28575455 | http://purl.uniprot.org/core/author | "Sakharkar A.J."xsd:string |
| http://purl.uniprot.org/citations/28575455 | http://purl.uniprot.org/core/author | "Pandey S.C."xsd:string |
| http://purl.uniprot.org/citations/28575455 | http://purl.uniprot.org/core/author | "Kokare D.M."xsd:string |
| http://purl.uniprot.org/citations/28575455 | http://purl.uniprot.org/core/author | "Kyzar E.J."xsd:string |
| http://purl.uniprot.org/citations/28575455 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28575455 | http://purl.uniprot.org/core/name | "Int J Neuropsychopharmacol"xsd:string |
| http://purl.uniprot.org/citations/28575455 | http://purl.uniprot.org/core/pages | "758-768"xsd:string |
| http://purl.uniprot.org/citations/28575455 | http://purl.uniprot.org/core/title | "Adolescent Alcohol Exposure-Induced Changes in Alpha-Melanocyte Stimulating Hormone and Neuropeptide Y Pathways via Histone Acetylation in the Brain During Adulthood."xsd:string |
| http://purl.uniprot.org/citations/28575455 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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