| http://purl.uniprot.org/citations/28583049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28583049 | http://www.w3.org/2000/01/rdf-schema#comment | "Anandamide, an endocannabinoid, inhibits aversive responses by activating the CB1 cannabinoid receptor. At high concentrations, however, anandamide may exert pro-aversive activities mediated by the transient receptor potential vanilloid type-1 channel (TRPV1). Accordingly, N-arachidonoyl-serotonin (AA-5-HT), a dual blocker of the anandamide-hydrolysing enzyme fatty acid amide hydrolase (FAAH) and the TRPV1 channel, induces anxiolytic-like effects. Here we tested the hypothesis that AA-5-HT inhibits the expression of contextual fear conditioning by facilitating CB1 receptor signalling in the dorsal hippocampus of mice. Intraperitoneal injection of AA-5-HT (0.1, 0.3, 1 mg/kg) inhibited the retrieval of contextual fear memory (freezing response). The effect of AA-5-HT (0.3 mg/kg) was prevented by systemic injection of the CB1 receptor antagonist, AM251 (1.0 mg/kg), and mimicked by simultaneous FAAH inhibition (URB597, 0.3 mg/kg) and TRPV1 blockage (SB366791, 1 mg/kg). Injection of AA-5-HT (0.125, 0.25, 0.5 nmol) into the dorsal hippocampus also reduced freezing. Finally, the effect of systemic AA-5-HT (0.3 mg/kg) was prevented by intra-hippocampal injection of AM251 (1 nmol). In conclusion, dual FAAH and TRPV1 blockage inhibits contextual fear memory by facilitating anandamide-induced CB1 receptor activation in the dorsal hippocampus. This approach may lead to new pharmacological treatments for traumatic memories and related psychiatric disorders."xsd:string |
| http://purl.uniprot.org/citations/28583049 | http://purl.org/dc/terms/identifier | "doi:10.1177/0269881117691567"xsd:string |
| http://purl.uniprot.org/citations/28583049 | http://purl.uniprot.org/core/author | "de Oliveira A.C."xsd:string |
| http://purl.uniprot.org/citations/28583049 | http://purl.uniprot.org/core/author | "Batista L.A."xsd:string |
| http://purl.uniprot.org/citations/28583049 | http://purl.uniprot.org/core/author | "Wotjak C.T."xsd:string |
| http://purl.uniprot.org/citations/28583049 | http://purl.uniprot.org/core/author | "Moreira F.A."xsd:string |
| http://purl.uniprot.org/citations/28583049 | http://purl.uniprot.org/core/author | "Resstel L.B."xsd:string |
| http://purl.uniprot.org/citations/28583049 | http://purl.uniprot.org/core/author | "Aguiar D.C."xsd:string |
| http://purl.uniprot.org/citations/28583049 | http://purl.uniprot.org/core/author | "Lima I.V."xsd:string |
| http://purl.uniprot.org/citations/28583049 | http://purl.uniprot.org/core/author | "Gobira P.H."xsd:string |
| http://purl.uniprot.org/citations/28583049 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28583049 | http://purl.uniprot.org/core/name | "J Psychopharmacol"xsd:string |
| http://purl.uniprot.org/citations/28583049 | http://purl.uniprot.org/core/pages | "750-756"xsd:string |
| http://purl.uniprot.org/citations/28583049 | http://purl.uniprot.org/core/title | "N-arachidonoyl-serotonin, a dual FAAH and TRPV1 blocker, inhibits the retrieval of contextual fear memory: Role of the cannabinoid CB1 receptor in the dorsal hippocampus."xsd:string |
| http://purl.uniprot.org/citations/28583049 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/28583049 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28583049 |
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