| http://purl.uniprot.org/citations/28593951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28593951 | http://www.w3.org/2000/01/rdf-schema#comment | "Matrix metalloproteinases (MMPs) contribute to the breakdown of tissue structures such as the basement membrane, promoting tissue fibrosis. Here we developed an electrospun membrane biofunctionalized with a fragment of the laminin β1-chain to modulate the expression of MMP2 in this context. We demonstrate that interfacing of the β1-fragment with the mesothelium of the peritoneal membrane via a biomaterial abrogates the release of active MMP2 in response to transforming growth factor β1 and rescues tissue integrity ex vivo and in vivo in a mouse model of peritoneal fibrosis. Importantly, our data demonstrate that the membrane inhibits MMP2 expression. Changes in the expression of epithelial-to-mesenchymal transition (EMT)-related molecules further point towards a contribution of the modulation of EMT. Biomaterial-based presentation of regulatory basement membrane signals directly addresses limitations of current therapeutic approaches by enabling a localized and specific method to counteract MMP2 release applicable to a broad range of therapeutic targets."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms15509"xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "Lopez-Cabrera M."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "Tryggvason K."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "Wang A.J."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "da Silva P.B."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "Stevens M.M."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "Horejs C.M."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "Maynard S.A."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "von Erlach T."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "Rynne-Vidal A."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "Hansel C.S."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "Mazo M.M."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "Ojala J.R.M."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "Rodriguez-Fernandez C."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "St-Pierre J.P."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "Steele J.A.M."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/author | "You A.Y.F."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/pages | "15509"xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/title | "Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information."xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/28593951 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28593951 |