| http://purl.uniprot.org/citations/28594325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28594325 | http://www.w3.org/2000/01/rdf-schema#comment | "RIG-I is a key cytosolic pattern recognition receptor that interacts with MAVS to induce type I interferons (IFNs) against RNA virus infection. In this study, we found that cyclophilin A (CypA), a peptidyl-prolyl cis/trans isomerase, functioned as a critical positive regulator of RIG-I-mediated antiviral immune responses. Deficiency of CypA impaired RIG-I-mediated type I IFN production and promoted viral replication in human cells and mice. Upon Sendai virus infection, CypA increased the interaction between RIG-I and its E3 ubiquitin ligase TRIM25, leading to enhanced TRIM25-mediated K63-linked ubiquitination of RIG-I that facilitated recruitment of RIG-I to MAVS. In addition, CypA and TRIM25 competitively interacted with MAVS, thereby inhibiting TRIM25-induced K48-linked ubiquitination of MAVS. Taken together, our findings reveal an essential role of CypA in boosting RIG-I-mediated antiviral immune responses by controlling the ubiquitination of RIG-I and MAVS."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.24425"xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/author | "Bi Y."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/author | "Shang Y."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/author | "Zheng W."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/author | "Zhao Z."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/author | "Duan Z."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/author | "Wang Y.L."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/author | "Jiang Z."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/author | "Liu W.'"xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/pages | "e24425"xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/title | "Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses."xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/28594325 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28594325 |
| http://purl.uniprot.org/citations/28594325 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28594325 |