DESCRIBE <http://purl.uniprot.org/citations/28599085>

Subject	Predicate	Object
http://purl.uniprot.org/citations/28599085	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/28599085	http://www.w3.org/2000/01/rdf-schema#comment	" Background Remote ischemic preconditioning (RIPC) is a phenomenon whereby transient nonlethal ischemia and reperfusion episodes confer protection against prolonged ischemia reperfusion-induced injury. However, the underlying intracellular signaling has not been extensively explored. Objective This study aimed to inspect the putative involvement of TRPV1 -dependent CGRP release in mediating remote hind limb preconditioning-induced cardioprotection. Methods In this study, remote hind limb preconditioning stimulus was delivered (four consecutive episodes of 5 minutes of ischemia reperfusion) using a blood pressure cuff tied at the inguinal level of the rat. The isolated rat hearts were perfused on the Langendorff's system and were subjected to 30-minutes global ischemia and 120-minutes reperfusion. Prolonged ischemia and subsequent reperfusion led to myocardial injury that was evaluated in terms of infarct size, LDH release, CK release, LVDP, +dp/dtmax , -dp/dtmin , and coronary flow rate. The pharmacological agents used in this study included capsaicin as TRPV1 channel activator, sumatriptan and CGRP8-37 as CGRP blockers. Results Remote hind limb and capsaicin preconditioning (10 mg/kg-1 ) significantly reduced the infarct size, LDH release, CK release and significantly improved LVDP, +dp/dtmax , -dp/dtmin , and coronary flow rate. However, remote hind limb and capsaicin preconditioning-induced cardioprotective effects were remarkably reduced in the presence of sumatriptan (8 mg/kg-1 ) and CGRP8-37 (1 mg/kg-1 ). Conclusion This indicates that remote hind limb preconditioning stimulus probably activates TRPV1 channels which subsequently induces CGRP release to produce cardioprotective effects."xsd:string
http://purl.uniprot.org/citations/28599085	http://purl.org/dc/terms/identifier	"doi:10.1111/1755-5922.12276"xsd:string
http://purl.uniprot.org/citations/28599085	http://purl.uniprot.org/core/author	"Jaggi A.S."xsd:string
http://purl.uniprot.org/citations/28599085	http://purl.uniprot.org/core/author	"Randhawa P.K."xsd:string
http://purl.uniprot.org/citations/28599085	http://purl.uniprot.org/core/date	"2017"xsd:gYear
http://purl.uniprot.org/citations/28599085	http://purl.uniprot.org/core/name	"Cardiovasc Ther"xsd:string
http://purl.uniprot.org/citations/28599085	http://purl.uniprot.org/core/title	"Exploring the putative role of TRPV1 -dependent CGRP release in remote hind preconditioning-induced cardioprotection."xsd:string
http://purl.uniprot.org/citations/28599085	http://purl.uniprot.org/core/volume	"35"xsd:string
http://purl.uniprot.org/citations/28599085	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/28599085
http://purl.uniprot.org/citations/28599085	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/28599085
http://purl.uniprot.org/uniprot/#_A0A0G2JSX2-mappedCitation-28599085	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28599085
http://purl.uniprot.org/uniprot/#_A6I8B3-mappedCitation-28599085	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28599085
http://purl.uniprot.org/uniprot/#_A6I8B8-mappedCitation-28599085	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28599085
http://purl.uniprot.org/uniprot/#_A6I8B9-mappedCitation-28599085	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28599085
http://purl.uniprot.org/uniprot/#_P01256-mappedCitation-28599085	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28599085
http://purl.uniprot.org/uniprot/#_P01257-mappedCitation-28599085	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28599085
http://purl.uniprot.org/uniprot/#_Q66VC1-mappedCitation-28599085	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/28599085
http://purl.uniprot.org/uniprot/A6I8B8	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/28599085
http://purl.uniprot.org/uniprot/P01257	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/28599085
http://purl.uniprot.org/uniprot/P01256	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/28599085
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http://purl.uniprot.org/uniprot/A6I8B9	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/28599085
http://purl.uniprot.org/uniprot/A0A0G2JSX2	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/28599085
http://purl.uniprot.org/uniprot/A6I8B3	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/28599085