| http://purl.uniprot.org/citations/28600811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28600811 | http://www.w3.org/2000/01/rdf-schema#comment | "Pregnancy-associated plasma protein-A (PAPP-A) knockout (KO) mice, generated through homologous recombination in embryonic stem cells, have a significantly increased lifespan compared to wild-type littermates. However, it is unknown whether this longevity advantage would pertain to PAPP-A gene deletion in adult animals. In the present study, we used tamoxifen (Tam)-inducible Cre recombinase-mediated excision of the floxed PAPP-A (fPAPP-A) gene in mice at 5 months of age. fPAPP-A mice, which were either positive (pos) or negative (neg) for Tam-Cre, received Tam treatment with quarterly boosters. Only female mice could be used with this experimental design. fPAPP-A/neg and fPAPP-A/pos mice had similar weights at the start of the experiment and showed equivalent weight gain. We found that fPAPP-A/pos mice had a significant extension of life span (P = 0.005). The median life span was increased by 21% for fPAPP-A/pos compared to fPAPP-A/neg mice. Analysis of mortality in life span quartiles indicated that the proportion of deaths of fPAPP-A/pos mice were lower than fPAPP-A/neg mice at young adult ages (P = 0.002 for 601-800 days) and higher than fPAPP-A/neg mice at older ages (P = 0.004 for >1000 days). Thus, survival curves and age-specific mortality indicate that female mice with knockdown of PAPP-A gene expression as adults have an extended healthy life span."xsd:string |
| http://purl.uniprot.org/citations/28600811 | http://purl.org/dc/terms/identifier | "doi:10.1111/acel.12624"xsd:string |
| http://purl.uniprot.org/citations/28600811 | http://purl.uniprot.org/core/author | "Conover C.A."xsd:string |
| http://purl.uniprot.org/citations/28600811 | http://purl.uniprot.org/core/author | "West S.A."xsd:string |
| http://purl.uniprot.org/citations/28600811 | http://purl.uniprot.org/core/author | "Bale L.K."xsd:string |
| http://purl.uniprot.org/citations/28600811 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28600811 | http://purl.uniprot.org/core/name | "Aging Cell"xsd:string |
| http://purl.uniprot.org/citations/28600811 | http://purl.uniprot.org/core/pages | "895-897"xsd:string |
| http://purl.uniprot.org/citations/28600811 | http://purl.uniprot.org/core/title | "Inducible knockdown of pregnancy-associated plasma protein-A gene expression in adult female mice extends life span."xsd:string |
| http://purl.uniprot.org/citations/28600811 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/28600811 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28600811 |
| http://purl.uniprot.org/citations/28600811 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28600811 |
| http://purl.uniprot.org/uniprot/#_Q8R4K8-mappedCitation-28600811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28600811 |
| http://purl.uniprot.org/uniprot/Q8R4K8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28600811 |