| http://purl.uniprot.org/citations/28601080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28601080 | http://www.w3.org/2000/01/rdf-schema#comment | "In the present study, we investigated the functional role of microRNA (miR)-630 in epithelial-to-mesenchymal transition (EMT) of gastric cancer (GC) cells, as well as the regulatory mechanism. Cells of human GC cell line SGC 7901 were transfected with miR-630 mimic or miR-630 inhibitor. The transfection efficiency was confirmed by qRT-PCR. Cell migration and invasion were determined by Transwell assay. Protein expression of E-cadherin, vimentin, and Forkhead box protein M1 (FoxM1) was tested by Western blot. Moreover, the expression of FoxM1 was elevated or suppressed, and then the effects of miR-630 abnormal expression on EMT and properties of migration and invasion were examined again, as well as protein expression of Ras/phosphoinositide 3-kinase (PI3K)/AKT related factors. The results showed that (i) the EMT and properties of migration and invasion were statistically decreased by overexpression of miR-630 compared to the control group but markedly increased by suppression of miR-630. However, (ii) abnormal expression of FoxM1 reversed these effects in GC cells. Moreover, (iii) expression of GTP-Rac1, p-PI3K, and p-AKT was decreased by miR-630 overexpression but increased by FoxM1 overexpression. (iv) The decreased levels of GTP-Rac1, p-PI3K, and p-AKT induced by miR-630 overexpression were dramatically elevated by simultaneous overexpression of FoxM1. In conclusion, our results suggest that miR-630 might be a tumor suppressor in GC cells. MiR-630 suppresses EMT by regulating FoxM1 in GC cells, supposedly via inactivation of the Ras/PI3K/AKT pathway."xsd:string |
| http://purl.uniprot.org/citations/28601080 | http://purl.org/dc/terms/identifier | "doi:10.1134/s0006297917060074"xsd:string |
| http://purl.uniprot.org/citations/28601080 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/28601080 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/28601080 | http://purl.uniprot.org/core/author | "Zhu W."xsd:string |
| http://purl.uniprot.org/citations/28601080 | http://purl.uniprot.org/core/author | "Feng J."xsd:string |
| http://purl.uniprot.org/citations/28601080 | http://purl.uniprot.org/core/author | "Feng C."xsd:string |
| http://purl.uniprot.org/citations/28601080 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28601080 | http://purl.uniprot.org/core/name | "Biochemistry (Mosc)"xsd:string |
| http://purl.uniprot.org/citations/28601080 | http://purl.uniprot.org/core/pages | "707-714"xsd:string |
| http://purl.uniprot.org/citations/28601080 | http://purl.uniprot.org/core/title | "MicroRNA-630 Suppresses Epithelial-to-Mesenchymal Transition by Regulating FoxM1 in Gastric Cancer Cells."xsd:string |
| http://purl.uniprot.org/citations/28601080 | http://purl.uniprot.org/core/volume | "82"xsd:string |
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