| http://purl.uniprot.org/citations/28602951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28602951 | http://www.w3.org/2000/01/rdf-schema#comment | "Efficient clearance of apoptotic cells is essential for tissue homeostasis in metazoans. Genetic studies in Caenorhabditis elegans have identified signaling cascades that activate CED-10/Rac1 GTPase and promote actin cytoskeletal rearrangement during apoptotic cell engulfment. However, the molecular connection between CED-10 activation and actin reorganization remains elusive. Here, we provide evidence that CED-10 binds to the Arp2/3 nucleation promoting factor WASP; CED-10 recruits WASP and Arp2/3 to apoptotic cell corpses in the phagocytes. The loss of WASP and Arp2/3 impaired cell corpse engulfment. Furthermore, we uncover that a WASP-activating factor SEM-5/GRB2 functions in the phagocytes to promote cell corpse clearance. Together, our results suggest CED-10 reorganizes the actin cytoskeleton by recruiting the WASP-Arp2/3 actin nucleation factors during apoptotic cell engulfment."xsd:string |
| http://purl.uniprot.org/citations/28602951 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2017.06.005"xsd:string |
| http://purl.uniprot.org/citations/28602951 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/28602951 | http://purl.uniprot.org/core/author | "Li W.'"xsd:string |
| http://purl.uniprot.org/citations/28602951 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/28602951 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/28602951 | http://purl.uniprot.org/core/author | "Chai Y."xsd:string |
| http://purl.uniprot.org/citations/28602951 | http://purl.uniprot.org/core/author | "Ou G."xsd:string |
| http://purl.uniprot.org/citations/28602951 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28602951 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/28602951 | http://purl.uniprot.org/core/pages | "215-223"xsd:string |
| http://purl.uniprot.org/citations/28602951 | http://purl.uniprot.org/core/title | "CED-10-WASP-Arp2/3 signaling axis regulates apoptotic cell corpse engulfment in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/28602951 | http://purl.uniprot.org/core/volume | "428"xsd:string |
| http://purl.uniprot.org/citations/28602951 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28602951 |
| http://purl.uniprot.org/citations/28602951 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28602951 |
| http://purl.uniprot.org/uniprot/#_P53489-mappedCitation-28602951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28602951 |
| http://purl.uniprot.org/uniprot/#_Q17795-mappedCitation-28602951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28602951 |
| http://purl.uniprot.org/uniprot/#_Q03206-mappedCitation-28602951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28602951 |
| http://purl.uniprot.org/uniprot/#_Q8MQE6-mappedCitation-28602951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28602951 |
| http://purl.uniprot.org/uniprot/Q17795 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28602951 |
| http://purl.uniprot.org/uniprot/Q03206 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28602951 |
| http://purl.uniprot.org/uniprot/Q8MQE6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28602951 |
| http://purl.uniprot.org/uniprot/P53489 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28602951 |