| http://purl.uniprot.org/citations/28607035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28607035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28607035 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA-dependent activator of interferon regulatory factors/Z-DNA binding protein 1 (DAI/ZBP1) is a crucial sensor of necroptotic cell death induced by murine cytomegalovirus (MCMV) in its natural host. Here, we show that viral capsid transport to the nucleus and subsequent viral IE3-dependent early transcription are required for necroptosis. Necroptosis induction does not depend on input virion DNA or newly synthesized viral DNA A putative RNA-binding domain of DAI/ZBP1, Zα2, is required to sense virus and trigger necroptosis. Thus, MCMV IE3-dependent transcription from the viral genome plays a crucial role in activating DAI/ZBP1-dependent necroptosis. This implicates RNA transcripts generated by a large double-stranded DNA virus as a biologically relevant ligand for DAI/ZBP1 during natural viral infection."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.org/dc/terms/identifier | "doi:10.15252/embr.201743947"xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.org/dc/terms/identifier | "doi:10.15252/embr.201743947"xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/author | "Kaiser W.J."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/author | "Kaiser W.J."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/author | "Guo H."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/author | "Guo H."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/author | "Upton J.W."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/author | "Upton J.W."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/author | "Gilley R.P."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/author | "Gilley R.P."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/author | "Landsteiner V.J."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/author | "Landsteiner V.J."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/author | "Ragan K.B."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/author | "Ragan K.B."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/author | "Sridharan H."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/author | "Sridharan H."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/name | "EMBO Rep."xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/pages | "1429-1441"xsd:string |
| http://purl.uniprot.org/citations/28607035 | http://purl.uniprot.org/core/pages | "1429-1441"xsd:string |