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| http://purl.uniprot.org/citations/28608855 | http://www.w3.org/2000/01/rdf-schema#comment | "Although autism spectrum disorders (ASDs) share a core set of nosological features, they exhibit substantial genetic heterogeneity. A parsimonious hypothesis posits that dysregulated epigenetic mechanisms represent common pathways in the etiology of ASDs. To investigate this hypothesis, we generated a novel mouse model resulting from brain-specific deletion of chromodomain helicase DNA-binding 5 (Chd5), a chromatin remodeling protein known to regulate neuronal differentiation and a member of a gene family strongly implicated in ASDs. RNA sequencing of Chd5-/- mouse forebrain tissue revealed a preponderance of changes in expression of genes important in cellular development and signaling, sociocommunicative behavior and ASDs. Pyramidal neurons cultured from Chd5-/- cortex displayed alterations in dendritic morphology. Paralleling ASD nosology, Chd5-/- mice exhibited abnormal sociocommunicative behavior and a strong preference for familiarity. Chd5-/- mice further showed deficits in responding to the distress of a conspecific, a mouse homolog of empathy. Thus, dysregulated chromatin remodeling produces a pattern of transcriptional, neuronal and behavioral effects consistent with the presentation of ASDs."xsd:string |
| http://purl.uniprot.org/citations/28608855 | http://purl.org/dc/terms/identifier | "doi:10.1038/tp.2017.111"xsd:string |
| http://purl.uniprot.org/citations/28608855 | http://purl.uniprot.org/core/author | "O'Connor M.B."xsd:string |
| http://purl.uniprot.org/citations/28608855 | http://purl.uniprot.org/core/author | "Bagchi A."xsd:string |
| http://purl.uniprot.org/citations/28608855 | http://purl.uniprot.org/core/author | "Gewirtz J.C."xsd:string |
| http://purl.uniprot.org/citations/28608855 | http://purl.uniprot.org/core/author | "Young A.E."xsd:string |
| http://purl.uniprot.org/citations/28608855 | http://purl.uniprot.org/core/author | "Gottesman I.I."xsd:string |
| http://purl.uniprot.org/citations/28608855 | http://purl.uniprot.org/core/author | "Pisansky M.T."xsd:string |
| http://purl.uniprot.org/citations/28608855 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28608855 | http://purl.uniprot.org/core/name | "Transl Psychiatry"xsd:string |
| http://purl.uniprot.org/citations/28608855 | http://purl.uniprot.org/core/pages | "e1152"xsd:string |
| http://purl.uniprot.org/citations/28608855 | http://purl.uniprot.org/core/title | "Mice lacking the chromodomain helicase DNA-binding 5 chromatin remodeler display autism-like characteristics."xsd:string |
| http://purl.uniprot.org/citations/28608855 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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