| http://purl.uniprot.org/citations/28609484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28609484 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectivesTo evaluate the prognostic effect of the Heterogeneous nuclear ribonucleoprotein type M (HNRPM) and Solute carrier 1A5 (SLC1A5) in FIGO-stages I-II epithelial ovarian cancer.MethodsA retrospective cohort study was designed to investigate the prognostic effect of HNRPM and SLC1A5, and the association with clinical-pathologic characteristics in 131 patients with FIGO-stages I-II epithelial ovarian cancer. Tissue microarrays were constructed and protein levels were assessed by immunohistochemistry (IHC).ResultsPositive HRNPM status was associated with positive staining for PUMA (P = 0.04), concomitant PUMA and p21 staining (P = 0.005), and VEGF-R2 (P = 0.003). Positive SLC1A5 staining was associated with positive staining of p27 (P = 0.030), PUMA (P = 0.039), concomitant PUMA and p27 staining, and VEGF-R2 (P = 0.039). In non-serous tumors (n = 72), the SLC1A5 positivity was associated with recurrent disease (P = 0.01). In a multivariable logistic regression analysis FIGO-stage (OR = 12.4), tumor grade (OR = 5.1) and SLC1A5 positivity (OR = 0.1) were independent predictive factors for recurrent disease. Disease-free survival (DFS) in women with SLC1A5-positive non-serous tumors was 92% compared with of 66% in patients with SLC1A5-negative non-serous tumors (Log-rank = 15.343; P = 0.008). In Cox analysis with DFS as endpoint, FIGO-stage (HR = 4.5) and SLC1A5 status (HR = 0.3) were prognostic factors.ConclusionsAs the proteins HRNPM and SLC1A5 are associated with the cell cycle regulators p21 or p27, the apoptosis regulators PTEN and PUMA, and the VEGF-R2 it is concluded that both proteins have role in the pathogenesis of ovarian cancer. In patients with non-serous ovarian cancer SLC1A5 protects from recurrent disease, presumably by means of biological mechanisms that are unrelated to cytotoxic drug sensitivity."xsd:string |
| http://purl.uniprot.org/citations/28609484 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0179363"xsd:string |
| http://purl.uniprot.org/citations/28609484 | http://purl.uniprot.org/core/author | "Akerud H."xsd:string |
| http://purl.uniprot.org/citations/28609484 | http://purl.uniprot.org/core/author | "Sundstrom-Poromaa I."xsd:string |
| http://purl.uniprot.org/citations/28609484 | http://purl.uniprot.org/core/author | "Seidal T."xsd:string |
| http://purl.uniprot.org/citations/28609484 | http://purl.uniprot.org/core/author | "Skirnisdottir I."xsd:string |
| http://purl.uniprot.org/citations/28609484 | http://purl.uniprot.org/core/author | "Bjersand K."xsd:string |
| http://purl.uniprot.org/citations/28609484 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28609484 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/28609484 | http://purl.uniprot.org/core/pages | "e0179363"xsd:string |
| http://purl.uniprot.org/citations/28609484 | http://purl.uniprot.org/core/title | "The clinical and prognostic correlation of HRNPM and SLC1A5 in pathogenesis and prognosis in epithelial ovarian cancer."xsd:string |
| http://purl.uniprot.org/citations/28609484 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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