| http://purl.uniprot.org/citations/28611371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28611371 | http://www.w3.org/2000/01/rdf-schema#comment | "The induction of host cell autophagy by various autophagy inducers contributes to the antimicrobial host defense against Mycobacterium tuberculosis (Mtb), a major pathogenic strain that causes human tuberculosis. In this study, we present a role for the newly identified cyclic peptides ohmyungsamycins (OMS) A and B in the antimicrobial responses against Mtb infections by activating autophagy in murine bone marrow-derived macrophages (BMDMs). OMS robustly activated autophagy, which was essentially required for the colocalization of LC3 autophagosomes with bacterial phagosomes and antimicrobial responses against Mtb in BMDMs. Using a Drosophila melanogaster-Mycobacterium marinum infection model, we showed that OMS-A-induced autophagy contributed to the increased survival of infected flies and the limitation of bacterial load. We further showed that OMS triggered AMP-activated protein kinase (AMPK) activation, which was required for OMS-mediated phagosome maturation and antimicrobial responses against Mtb. Moreover, treating BMDMs with OMS led to dose-dependent inhibition of macrophage inflammatory responses, which was also dependent on AMPK activation. Collectively, these data show that OMS is a promising candidate for new anti-mycobacterial therapeutics by activating antibacterial autophagy via AMPK-dependent signaling and suppressing excessive inflammation during Mtb infections."xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-03477-3"xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/author | "Lee H.M."xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/author | "Kim J.K."xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/author | "Um S."xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/author | "Kim T.S."xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/author | "Komatsu M."xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/author | "Oh D.C."xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/author | "Jang J.C."xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/author | "Jin H.S."xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/author | "Jo E.K."xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/author | "Shin Y.H."xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/author | "Cha G.H."xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/author | "Chae H.J."xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/author | "Choe J.H."xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/pages | "3431"xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/title | "Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway."xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28611371 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28611371 |
| http://purl.uniprot.org/citations/28611371 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28611371 |
| http://purl.uniprot.org/uniprot/#_A1ZBA9-mappedCitation-28611371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28611371 |
| http://purl.uniprot.org/uniprot/#_Q7JY94-mappedCitation-28611371 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28611371 |