| http://purl.uniprot.org/citations/28612841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28612841 | http://www.w3.org/2000/01/rdf-schema#comment | "Intestinal fibrosis is a major complication in inflammatory bowel diseases, but the regulatory mechanism that inhibits fibrosis remains unclear. Here we demonstrate that Itch-/-myofibroblasts express increased amounts of profibrotic collagen type I and α-SMA in response to IL-17. Mechanistically, we demonstrate that Itch directly binds to HIC-5 and targets it for K63-linked ubiquitination to inhibit IL-17-driven intestinal fibrosis. Reconstitution of Itch-/- myofibroblasts with wild-type Itch but not the Itch-C830A mutant normalized the expression of profibrotic genes. Similarly, shRNA-mediated inhibition of HIC-5 normalized the expression of profibrotic gene expression. Thus, we have uncovered a novel mechanism by which Itch negatively regulates intestinal fibrosis."xsd:string |
| http://purl.uniprot.org/citations/28612841 | http://purl.org/dc/terms/identifier | "doi:10.1038/mi.2017.53"xsd:string |
| http://purl.uniprot.org/citations/28612841 | http://purl.uniprot.org/core/author | "Singh A.K."xsd:string |
| http://purl.uniprot.org/citations/28612841 | http://purl.uniprot.org/core/author | "Zeng M."xsd:string |
| http://purl.uniprot.org/citations/28612841 | http://purl.uniprot.org/core/author | "Basrur V."xsd:string |
| http://purl.uniprot.org/citations/28612841 | http://purl.uniprot.org/core/author | "Theiss A.L."xsd:string |
| http://purl.uniprot.org/citations/28612841 | http://purl.uniprot.org/core/author | "Venuprasad K."xsd:string |
| http://purl.uniprot.org/citations/28612841 | http://purl.uniprot.org/core/author | "Paul J."xsd:string |
| http://purl.uniprot.org/citations/28612841 | http://purl.uniprot.org/core/author | "Kathania M."xsd:string |
| http://purl.uniprot.org/citations/28612841 | http://purl.uniprot.org/core/author | "Elviche T.L."xsd:string |
| http://purl.uniprot.org/citations/28612841 | http://purl.uniprot.org/core/date | "2018"xsd:gYear |
| http://purl.uniprot.org/citations/28612841 | http://purl.uniprot.org/core/name | "Mucosal Immunol"xsd:string |
| http://purl.uniprot.org/citations/28612841 | http://purl.uniprot.org/core/pages | "427-436"xsd:string |
| http://purl.uniprot.org/citations/28612841 | http://purl.uniprot.org/core/title | "IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5."xsd:string |
| http://purl.uniprot.org/citations/28612841 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/28612841 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28612841 |
| http://purl.uniprot.org/citations/28612841 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28612841 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGZ6-mappedCitation-28612841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28612841 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J096-mappedCitation-28612841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28612841 |
| http://purl.uniprot.org/uniprot/#_A0A510NUK5-mappedCitation-28612841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28612841 |
| http://purl.uniprot.org/uniprot/#_A2ALT1-mappedCitation-28612841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28612841 |
| http://purl.uniprot.org/uniprot/#_A2ALT2-mappedCitation-28612841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28612841 |
| http://purl.uniprot.org/uniprot/#_A2BGG7-mappedCitation-28612841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28612841 |
| http://purl.uniprot.org/uniprot/#_E9Q1D5-mappedCitation-28612841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28612841 |