| http://purl.uniprot.org/citations/28615291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28615291 | http://www.w3.org/2000/01/rdf-schema#comment | "The mitochondrial calcium uniporter is a Ca2+-activated Ca2+ channel that is essential for dynamic modulation of mitochondrial function in response to cellular Ca2+ signals. It is regulated by two paralogous EF-hand proteins-MICU1 and MICU2, but the mechanism is unknown. Here, we demonstrate that both MICU1 and MICU2 are stabilized by Ca2+ We reconstitute the MICU1-MICU2 heterodimer and demonstrate that it binds Ca2+ cooperatively with high affinity. We discover that both MICU1 and MICU2 exhibit affinity for the mitochondria-specific lipid cardiolipin. We determine the minimum Ca2+ concentration required for disinhibition of the uniporter in permeabilized cells and report a close match with the Ca2+-binding affinity of MICU1-MICU2. We conclude that cooperative, high-affinity interaction of the MICU1-MICU2 complex with Ca2+ serves as an on-off switch, leading to a tightly controlled channel, capable of responding directly to cytosolic Ca2+ signals."xsd:string |
| http://purl.uniprot.org/citations/28615291 | http://purl.org/dc/terms/identifier | "doi:10.15252/embr.201643748"xsd:string |
| http://purl.uniprot.org/citations/28615291 | http://purl.uniprot.org/core/author | "Kamer K.J."xsd:string |
| http://purl.uniprot.org/citations/28615291 | http://purl.uniprot.org/core/author | "Mootha V.K."xsd:string |
| http://purl.uniprot.org/citations/28615291 | http://purl.uniprot.org/core/author | "Grabarek Z."xsd:string |
| http://purl.uniprot.org/citations/28615291 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28615291 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/28615291 | http://purl.uniprot.org/core/pages | "1397-1411"xsd:string |
| http://purl.uniprot.org/citations/28615291 | http://purl.uniprot.org/core/title | "High-affinity cooperative Capisup>2+pi/sup> binding by MICU1-MICU2 serves as an on-off switch for the uniporter."xsd:string |
| http://purl.uniprot.org/citations/28615291 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/28615291 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28615291 |
| http://purl.uniprot.org/citations/28615291 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28615291 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z6B0-mappedCitation-28615291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28615291 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z6V5-mappedCitation-28615291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28615291 |
| http://purl.uniprot.org/uniprot/#_Q8IYU8-mappedCitation-28615291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28615291 |
| http://purl.uniprot.org/uniprot/#_Q9BPX6-mappedCitation-28615291 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28615291 |
| http://purl.uniprot.org/uniprot/A0A0S2Z6B0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28615291 |
| http://purl.uniprot.org/uniprot/A0A0S2Z6V5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28615291 |
| http://purl.uniprot.org/uniprot/Q8IYU8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28615291 |
| http://purl.uniprot.org/uniprot/Q9BPX6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28615291 |