| http://purl.uniprot.org/citations/28623663 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28623663 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription initiation by RNA Polymerase I (Pol I) depends on the Core Factor (CF) complex to recognize the upstream promoter and assemble into a Pre-Initiation Complex (PIC). Here, we solve a structure of Saccharomyces cerevisiae Pol I-CF-DNA to 3.8 Å resolution using single-particle cryo-electron microscopy. The structure reveals a bipartite architecture of Core Factor and its recognition of the promoter from -27 to -16. Core Factor's intrinsic mobility correlates well with different conformational states of the Pol I cleft, in addition to the stabilization of either Rrn7 N-terminal domain near Pol I wall or the tandem winged helix domain of A49 at a partially overlapping location. Comparison of the three states in this study with the Pol II system suggests that a ratchet motion of the Core Factor-DNA sub-complex at upstream facilitates promoter melting in an ATP-independent manner, distinct from a DNA translocase actively threading the downstream DNA in the Pol II PIC."xsd:string |
| http://purl.uniprot.org/citations/28623663 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.27414"xsd:string |
| http://purl.uniprot.org/citations/28623663 | http://purl.uniprot.org/core/author | "Han Y."xsd:string |
| http://purl.uniprot.org/citations/28623663 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/28623663 | http://purl.uniprot.org/core/author | "Yan C."xsd:string |
| http://purl.uniprot.org/citations/28623663 | http://purl.uniprot.org/core/author | "Ivanov I."xsd:string |
| http://purl.uniprot.org/citations/28623663 | http://purl.uniprot.org/core/author | "Knutson B.A."xsd:string |
| http://purl.uniprot.org/citations/28623663 | http://purl.uniprot.org/core/author | "Nguyen T.H.D."xsd:string |
| http://purl.uniprot.org/citations/28623663 | http://purl.uniprot.org/core/author | "Jackobel A.J."xsd:string |
| http://purl.uniprot.org/citations/28623663 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28623663 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/28623663 | http://purl.uniprot.org/core/pages | "e27414"xsd:string |
| http://purl.uniprot.org/citations/28623663 | http://purl.uniprot.org/core/title | "Structural mechanism of ATP-independent transcription initiation by RNA polymerase I."xsd:string |
| http://purl.uniprot.org/citations/28623663 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/28623663 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28623663 |
| http://purl.uniprot.org/citations/28623663 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28623663 |
| http://purl.uniprot.org/uniprot/#_A0A8H4BVQ7-mappedCitation-28623663 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28623663 |
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| http://purl.uniprot.org/uniprot/#_A0A7I9G2N8-mappedCitation-28623663 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28623663 |
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| http://purl.uniprot.org/uniprot/#_P07703-mappedCitation-28623663 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28623663 |
| http://purl.uniprot.org/uniprot/#_P40992-mappedCitation-28623663 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28623663 |