| http://purl.uniprot.org/citations/28624525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28624525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28624525 | http://www.w3.org/2000/01/rdf-schema#comment | "Multidrug/multixenobiotic resistance (MDR/MXR) confers resistance to a diverse range of potentially toxic pharmaceuticals and environmental contaminants through a cellular response that involves the coordinated induction and activity of the ATP-binding cassette (ABC) transporter P-glycoprotein (P-gp) and the Phase I metabolizing enzyme cytochrome P450 3A (CYP3A). In mammals, ligand-mediated pregnane X receptor (PXR) transcriptional activity regulates the induction of P-gp and CYP3A; however, this mechanism has not been well-characterized in piscine species. Zebrafish (Danio rerio) treated with the Pxr agonist pregnenolone 16α-carbonitrile (PCN) showed decreased P-gp (zebrafish Abcb4) and CYP3A (zebrafish Cyp3a65) mRNA levels after 48h exposure; however, treatment with PCN also resulted in increased hepatic MDR/MXR functional activity (i.e. increased Rhodamine 123 efflux) in vivo. Consistent with mammalian-like MDR/MXR regulated by PXR, the PCN-mediated modulation of hepatic Abcb4 and Cyp3a65 mRNA levels and MDR/MXR functional activity was attenuated by co-treatment with PCN and the mammalian PXR antagonist, ketoconazole (KTC). These results provide evidence that zebrafish Pxr may play a role in MDR/MXR through transcriptional regulation of abcb4 and cyp3a65 gene expression."xsd:string |
| http://purl.uniprot.org/citations/28624525 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cbpc.2017.06.004"xsd:string |
| http://purl.uniprot.org/citations/28624525 | http://purl.uniprot.org/core/author | "Jackson J.S."xsd:string |
| http://purl.uniprot.org/citations/28624525 | http://purl.uniprot.org/core/author | "Jackson J.S."xsd:string |
| http://purl.uniprot.org/citations/28624525 | http://purl.uniprot.org/core/author | "Kennedy C.J."xsd:string |
| http://purl.uniprot.org/citations/28624525 | http://purl.uniprot.org/core/author | "Kennedy C.J."xsd:string |
| http://purl.uniprot.org/citations/28624525 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28624525 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28624525 | http://purl.uniprot.org/core/name | "Comp. Biochem. Physiol. C Toxicol. Pharmacol."xsd:string |
| http://purl.uniprot.org/citations/28624525 | http://purl.uniprot.org/core/name | "Comp Biochem Physiol C Toxicol Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/28624525 | http://purl.uniprot.org/core/pages | "34-41"xsd:string |
| http://purl.uniprot.org/citations/28624525 | http://purl.uniprot.org/core/pages | "34-41"xsd:string |
| http://purl.uniprot.org/citations/28624525 | http://purl.uniprot.org/core/title | "Regulation of hepatic abcb4 and cyp3a65 gene expression and multidrug/multixenobiotic resistance (MDR/MXR) functional activity in the model teleost, Danio rerio (zebrafish)."xsd:string |
| http://purl.uniprot.org/citations/28624525 | http://purl.uniprot.org/core/title | "Regulation of hepatic abcb4 and cyp3a65 gene expression and multidrug/multixenobiotic resistance (MDR/MXR) functional activity in the model teleost, Danio rerio (zebrafish)."xsd:string |
| http://purl.uniprot.org/citations/28624525 | http://purl.uniprot.org/core/volume | "200"xsd:string |
| http://purl.uniprot.org/citations/28624525 | http://purl.uniprot.org/core/volume | "200"xsd:string |
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| http://purl.uniprot.org/citations/28624525 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28624525 |
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| http://purl.uniprot.org/citations/28624525 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28624525 |
| http://purl.uniprot.org/uniprot/Q7ZTW6 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/28624525 |
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| http://purl.uniprot.org/uniprot/#_A5WYG8-citation-28624525 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28624525 |