| http://purl.uniprot.org/citations/28625552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28625552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28625552 | http://www.w3.org/2000/01/rdf-schema#comment | "Circular RNAs (circRNAs) generated via back-splicing are enhanced by flanking complementary sequences. Expression levels of circRNAs vary under different conditions, suggesting participation of protein factors in their biogenesis. Using genome-wide siRNA screening that targets all human unique genes and an efficient circRNA expression reporter, we identify double-stranded RNA-binding domain containing immune factors NF90/NF110 as key regulators in circRNA biogenesis. NF90/NF110 promote circRNA production in the nucleus by associating with intronic RNA pairs juxtaposing the circRNA-forming exon(s); they also interact with mature circRNAs in the cytoplasm. Upon viral infection, circRNA expression is decreased, in part owing to the nuclear export of NF90/NF110 to the cytoplasm. Meanwhile, NF90/NF110 released from circRNP complexes bind to viral mRNAs as part of their functions in antiviral immune response. Our results therefore implicate a coordinated regulation of circRNA biogenesis and function by NF90/NF110 in viral infection."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2017.05.023"xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2017.05.023"xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Jiang S."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Jiang S."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Wei J."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Wei J."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Xue W."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Xue W."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Liu C.X."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Liu C.X."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Chen L.L."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Chen L.L."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Yao R.W."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Yao R.W."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Yin Q.F."xsd:string |
| http://purl.uniprot.org/citations/28625552 | http://purl.uniprot.org/core/author | "Yin Q.F."xsd:string |