| http://purl.uniprot.org/citations/28628040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28628040 | http://www.w3.org/2000/01/rdf-schema#comment | "Epidemiologic and animal studies implicate overconsumption of fructose in the development of nonalcoholic fatty liver disease, but the molecular mechanisms underlying fructose-induced chronic liver diseases remain largely unknown. Here, we have presented evidence supporting the essential function of the lipogenic transcription factor carbohydrate response element-binding protein (ChREBP) in mediating adaptive responses to fructose and protecting against fructose-induced hepatotoxicity. In WT mice, a high-fructose diet (HFrD) activated hepatic lipogenesis in a ChREBP-dependent manner; however, in Chrebp-KO mice, a HFrD induced steatohepatitis. In Chrebp-KO mouse livers, a HFrD reduced levels of molecular chaperones and activated the C/EBP homologous protein-dependent (CHOP-dependent) unfolded protein response, whereas administration of a chemical chaperone or Chop shRNA rescued liver injury. Elevated expression levels of cholesterol biosynthesis genes in HFrD-fed Chrebp-KO livers were paralleled by an increased nuclear abundance of sterol regulatory element-binding protein 2 (SREBP2). Atorvastatin-mediated inhibition of hepatic cholesterol biosynthesis or depletion of hepatic Srebp2 reversed fructose-induced liver injury in Chrebp-KO mice. Mechanistically, we determined that ChREBP binds to nuclear SREBP2 to promote its ubiquitination and destabilization in cultured cells. Therefore, our findings demonstrate that ChREBP provides hepatoprotection against a HFrD by preventing overactivation of cholesterol biosynthesis and the subsequent CHOP-mediated, proapoptotic unfolded protein response. Our findings also identified a role for ChREBP in regulating SREBP2-dependent cholesterol metabolism."xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci89934"xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/author | "Lin J."xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/author | "Gupta N."xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/author | "Meng Z."xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/author | "Tong X."xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/author | "Yin L."xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/author | "Rui L."xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/author | "Omary M.B."xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/author | "Brady G.F."xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/author | "Stamper K."xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/author | "VanDommelen K."xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/pages | "2855-2867"xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/title | "Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity."xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/28628040 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28628040 |
| http://purl.uniprot.org/citations/28628040 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28628040 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUR1-mappedCitation-28628040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28628040 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUT0-mappedCitation-28628040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28628040 |
| http://purl.uniprot.org/uniprot/#_H9U1Q1-mappedCitation-28628040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28628040 |
| http://purl.uniprot.org/uniprot/#_F6Q3B6-mappedCitation-28628040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28628040 |