| http://purl.uniprot.org/citations/28628091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28628091 | http://www.w3.org/2000/01/rdf-schema#comment | "Developing pre-B cells in the bone marrow alternate between proliferation and differentiation phases. We found that protein arginine methyl transferase 1 (PRMT1) and B cell translocation gene 2 (BTG2) are critical components of the pre-B cell differentiation program. The BTG2-PRMT1 module induced a cell-cycle arrest of pre-B cells that was accompanied by re-expression of Rag1 and Rag2 and the onset of immunoglobulin light chain gene rearrangements. We found that PRMT1 methylated cyclin-dependent kinase 4 (CDK4), thereby preventing the formation of a CDK4-Cyclin-D3 complex and cell cycle progression. Moreover, BTG2 in concert with PRMT1 efficiently blocked the proliferation of BCR-ABL1-transformed pre-B cells in vitro and in vivo. Our results identify a key molecular mechanism by which the BTG2-PRMT1 module regulates pre-B cell differentiation and inhibits pre-B cell leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.3774"xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/author | "Singh A."xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/author | "Warscheid B."xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/author | "Infantino S."xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/author | "Drepper F."xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/author | "Reth M."xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/author | "Jumaa H."xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/author | "Medgyesi D."xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/author | "Tarlinton D.M."xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/author | "Minguet S."xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/author | "Wossning T."xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/author | "Fiala G.J."xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/author | "Borsig T."xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/author | "Dolezal E."xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/pages | "911-920"xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/title | "The BTG2-PRMT1 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex."xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/28628091 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28628091 |
| http://purl.uniprot.org/citations/28628091 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28628091 |
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| http://purl.uniprot.org/uniprot/#_D3YWR2-mappedCitation-28628091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28628091 |