| http://purl.uniprot.org/citations/28629331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28629331 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundP21-activated kinase 1 (PAK1) stimulates growth and metastasis of colorectal cancer (CRC) through activation of multiple signalling pathways. Up-regulation of CRC stem cell markers by PAK1 also contributes to the resistance of CRC to 5-fluorouracil. The aim of this study was to investigate the effect of PAK1 depletion and inhibition on the immune system and on intestinal tumour formation in APC∆14/+ mice.MethodsThe PAK1 KO APC∆14/+ mice were generated by cross-breeding of PAK1 KO mice with APC∆14/+ mice. Splenic lymphocytes were analysed by flow cytometry, and immunohistochemical staining. The numbers of intestinal tumours were counted. Blood cells were also counted.ResultsCompared to APC+/+ mice, the numbers of both T- and B-lymphocytes were reduced in the spleen of APC∆14/+ mice. Depletion of PAK1 in APC∆14/+ mice increased the numbers of splenic T- and B-lymphocytes and decreased the numbers of intestinal tumours. Treatment of APC∆14/+ mice with PF-3758309, a PAK inhibitor reduced the numbers of intestinal tumours and increased the numbers of blood lymphocytes.ConclusionDepletion of active PAK1 up-regulates the immune system of APC∆14/+ mice and suppresses intestinal tumour development. These observations suggest an important role for PAK1 in the immune response to tumours."xsd:string |
| http://purl.uniprot.org/citations/28629331 | http://purl.org/dc/terms/identifier | "doi:10.1186/s12885-017-3432-0"xsd:string |
| http://purl.uniprot.org/citations/28629331 | http://purl.uniprot.org/core/author | "He H."xsd:string |
| http://purl.uniprot.org/citations/28629331 | http://purl.uniprot.org/core/author | "Wang K."xsd:string |
| http://purl.uniprot.org/citations/28629331 | http://purl.uniprot.org/core/author | "Sandrin M.S."xsd:string |
| http://purl.uniprot.org/citations/28629331 | http://purl.uniprot.org/core/author | "Baldwin G.S."xsd:string |
| http://purl.uniprot.org/citations/28629331 | http://purl.uniprot.org/core/author | "Huynh N."xsd:string |
| http://purl.uniprot.org/citations/28629331 | http://purl.uniprot.org/core/author | "Yim M."xsd:string |
| http://purl.uniprot.org/citations/28629331 | http://purl.uniprot.org/core/author | "Nikfarjam M."xsd:string |
| http://purl.uniprot.org/citations/28629331 | http://purl.uniprot.org/core/author | "Dumesny C.J."xsd:string |
| http://purl.uniprot.org/citations/28629331 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28629331 | http://purl.uniprot.org/core/name | "BMC Cancer"xsd:string |
| http://purl.uniprot.org/citations/28629331 | http://purl.uniprot.org/core/pages | "431"xsd:string |
| http://purl.uniprot.org/citations/28629331 | http://purl.uniprot.org/core/title | "Depletion of p21-activated kinase 1 up-regulates the immune system of APCpisup>∆14/+pi/sup> mice and inhibits intestinal tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/28629331 | http://purl.uniprot.org/core/volume | "17"xsd:string |
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