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| http://purl.uniprot.org/citations/28630144 | http://www.w3.org/2000/01/rdf-schema#comment | "Cells can control actin polymerization by nucleating new filaments or elongating existing ones. We recently identified CRMP-1 as a factor that stimulates the formation of Listeria monocytogenes actin comet tails, thereby implicating it in actin assembly. We now show that CRMP-1 is a major contributor to actin assembly in epithelial cells, where it works with the Ena/VASP family member EVL to assemble the actin cytoskeleton in the apical cortex and in protruding lamellipodia. CRMP-1 and EVL bind to one another and together accelerate actin filament barbed-end elongation. CRMP-1 also stimulates actin assembly in the presence of VASP and Mena in vitro, but CRMP-1-dependent actin assembly in MDCK cells is EVL specific. Our results identify CRMP-1 as a novel regulator of actin filament elongation and reveal a surprisingly important role for CRMP-1, EVL, and actin polymerization in maintaining the structural integrity of epithelial sheets."xsd:string |
| http://purl.uniprot.org/citations/28630144 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201606084"xsd:string |
| http://purl.uniprot.org/citations/28630144 | http://purl.uniprot.org/core/author | "Brieher W.M."xsd:string |
| http://purl.uniprot.org/citations/28630144 | http://purl.uniprot.org/core/author | "Yu-Kemp H.C."xsd:string |
| http://purl.uniprot.org/citations/28630144 | http://purl.uniprot.org/core/author | "Kemp J.P. Jr."xsd:string |
| http://purl.uniprot.org/citations/28630144 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28630144 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/28630144 | http://purl.uniprot.org/core/pages | "2463-2479"xsd:string |
| http://purl.uniprot.org/citations/28630144 | http://purl.uniprot.org/core/title | "CRMP-1 enhances EVL-mediated actin elongation to build lamellipodia and the actin cortex."xsd:string |
| http://purl.uniprot.org/citations/28630144 | http://purl.uniprot.org/core/volume | "216"xsd:string |
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