| http://purl.uniprot.org/citations/28630165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28630165 | http://www.w3.org/2000/01/rdf-schema#comment | "The immunoglobulin superfamily adhesion molecule close homolog of L1 (CHL1) plays important roles during nervous system development. Here, we identified the hedgehog receptor patched-1 (PTCH1) as a novel CHL1-binding protein and showed that CHL1 interacts with the first extracellular loop of PTCH1 via its extracellular domain. Colocalization and co-immunoprecipitation of CHL1 with PTCH1 suggest an association of CHL1 with this major component of the hedgehog signaling pathway. The trans-interaction of CHL1 with PTCH1 promotes neuronal survival in cultures of dissociated cerebellar granule cells and of organotypic cerebellar slices. An inhibitor of the PTCH1-regulated hedgehog signal transducer, smoothened (SMO), and inhibitors of RhoA and Rho-associated kinase (ROCK) 1 and 2 prevent CHL1-dependent survival of cultured cerebellar granule cells and survival of cerebellar granule and Purkinje cells in organotypic cultures. In histological sections from 10- and 14-day-old CHL1-deficient mice, enhanced apoptosis of granule, but not Purkinje, cells was observed. The results of the present study indicate that CHL1 triggers PTCH1-, SMO-, RhoA- and ROCK-dependent signal transduction pathways to promote neuronal survival after cessation of the major morphogenetic events during mouse cerebellar development."xsd:string |
| http://purl.uniprot.org/citations/28630165 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.194563"xsd:string |
| http://purl.uniprot.org/citations/28630165 | http://purl.uniprot.org/core/author | "Schachner M."xsd:string |
| http://purl.uniprot.org/citations/28630165 | http://purl.uniprot.org/core/author | "Kleene R."xsd:string |
| http://purl.uniprot.org/citations/28630165 | http://purl.uniprot.org/core/author | "Loers G."xsd:string |
| http://purl.uniprot.org/citations/28630165 | http://purl.uniprot.org/core/author | "Katic J."xsd:string |
| http://purl.uniprot.org/citations/28630165 | http://purl.uniprot.org/core/author | "Tosic J."xsd:string |
| http://purl.uniprot.org/citations/28630165 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28630165 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/28630165 | http://purl.uniprot.org/core/pages | "2606-2619"xsd:string |
| http://purl.uniprot.org/citations/28630165 | http://purl.uniprot.org/core/title | "The cell adhesion molecule CHL1 interacts with patched-1 to regulate apoptosis during postnatal cerebellar development."xsd:string |
| http://purl.uniprot.org/citations/28630165 | http://purl.uniprot.org/core/volume | "130"xsd:string |
| http://purl.uniprot.org/citations/28630165 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28630165 |
| http://purl.uniprot.org/citations/28630165 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28630165 |
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