| http://purl.uniprot.org/citations/28630501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28630501 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic polymorphisms in IFNL4 have been shown to predict responses to IFN-α-based therapy in hepatitis C virus (HCV)-infected patients. The IFNL4-ΔG genotype, which encodes functional IFN-λ4 protein, is associated with a poor treatment response. In the present study, we investigated the induction and biological effects of IFN-λ4 in HCV-infected hepatocytes and their association with responsiveness to IFN-α. We also studied the effects of direct-acting antiviral (DAA) treatment on IFN-λ4 expression and IFN-α responsiveness. HCV infection induced IFN-λ4 expression at mRNA and protein levels in primary human hepatocytes (PHHs). In hepatoma cells, IFNL4 gene transfection or recombinant IFN-λ4 protein treatment robustly increased the protein levels of ISG15 and USP18 in an IFNLR1-dependent manner and potently blocked IFN-α signalling. The ISG15/USP18-mediated IFN-α unresponsiveness was demonstrated by transfection of siRNAs targeting ISG15 and/or USP18. This potent IFN-λ4 effect was related to prolonged ISG expression after IFNL4 gene transfection. DAA treatment of HCV-infected PHHs reduced the expression of IFN-λs, including IFN-λ4, and restored IFN-α responsiveness. These results demonstrate that virus-induced IFN-λ4 potently blocks IFN-α signalling by inducing high protein levels of ISG15 and USP18. Moreover, the data clearly demonstrate that DAA therapy restores IFN-α responsiveness in HCV-infected cells."xsd:string |
| http://purl.uniprot.org/citations/28630501 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41598-017-04186-7"xsd:string |
| http://purl.uniprot.org/citations/28630501 | http://purl.uniprot.org/core/author | "Hong S.H."xsd:string |
| http://purl.uniprot.org/citations/28630501 | http://purl.uniprot.org/core/author | "Kim H.M."xsd:string |
| http://purl.uniprot.org/citations/28630501 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/28630501 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/28630501 | http://purl.uniprot.org/core/author | "Chung J.H."xsd:string |
| http://purl.uniprot.org/citations/28630501 | http://purl.uniprot.org/core/author | "Yoon S.K."xsd:string |
| http://purl.uniprot.org/citations/28630501 | http://purl.uniprot.org/core/author | "Shin E.C."xsd:string |
| http://purl.uniprot.org/citations/28630501 | http://purl.uniprot.org/core/author | "Sung P.S."xsd:string |
| http://purl.uniprot.org/citations/28630501 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28630501 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/28630501 | http://purl.uniprot.org/core/pages | "3821"xsd:string |
| http://purl.uniprot.org/citations/28630501 | http://purl.uniprot.org/core/title | "IFN-lambda4 potently blocks IFN-alpha signalling by ISG15 and USP18 in hepatitis C virus infection."xsd:string |
| http://purl.uniprot.org/citations/28630501 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28630501 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28630501 |
| http://purl.uniprot.org/citations/28630501 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28630501 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C3A5-mappedCitation-28630501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28630501 |
| http://purl.uniprot.org/uniprot/#_K9M1A9-mappedCitation-28630501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28630501 |
| http://purl.uniprot.org/uniprot/#_K9M1I6-mappedCitation-28630501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28630501 |
| http://purl.uniprot.org/uniprot/#_K9M1I8-mappedCitation-28630501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28630501 |
| http://purl.uniprot.org/uniprot/#_K9M1U2-mappedCitation-28630501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28630501 |
| http://purl.uniprot.org/uniprot/#_K9M1U5-mappedCitation-28630501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28630501 |
| http://purl.uniprot.org/uniprot/#_K9M268-mappedCitation-28630501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28630501 |