| http://purl.uniprot.org/citations/28634224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28634224 | http://www.w3.org/2000/01/rdf-schema#comment | "Burkitt lymphoma/leukemia cells carry t(8;14)(q24;q32) chromosomal translocation encoding IGH/MYC, which results in the constitutive expression of the MYC oncogene. Here, it is demonstrated that untreated and cytarabine (AraC)-treated IGH/MYC-positive Burkitt lymphoma cells accumulate a high number of potentially lethal DNA double-strand breaks (DSB) and display low levels of the BRCA2 tumor suppressor protein, which is a key element of homologous recombination (HR)-mediated DSB repair. BRCA2 deficiency in IGH/MYC-positive cells was associated with diminished HR activity and hypersensitivity to PARP1 inhibitors (olaparib, talazoparib) used alone or in combination with cytarabine in vitro Moreover, talazoparib exerted a therapeutic effect in NGS mice bearing primary Burkitt lymphoma xenografts. In conclusion, IGH/MYC-positive Burkitt lymphoma/leukemia cells have decreased BRCA2 and are sensitive to PARP1 inhibition alone or in combination with other chemotherapies.Implications: This study postulates that IGH/MYC-induced BRCA2 deficiency may predispose Burkitt lymphoma cells to synthetic lethality triggered by PARP1 inhibitors.Visual Overview: http://mcr.aacrjournals.org/content/molcanres/15/8/967/F1.large.jpgMol Cancer Res; 15(8); 967-72. ©2017 AACR."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.org/dc/terms/identifier | "doi:10.1158/1541-7786.mcr-16-0468"xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Martin K."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Skorski T."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Sullivan-Reed K."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Nieborowska-Skorska M."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Wasik M.A."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Piwocka K."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Tempera I."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Podszywalow-Bartnicka P."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Dasgupta Y."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Hulse M."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Maifrede S."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Gritsyuk D."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Lupey-Green L.N."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Langer S.K."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/author | "Nejati R."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/name | "Mol Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/pages | "967-972"xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/title | "IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors."xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/28634224 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28634224 |