| http://purl.uniprot.org/citations/28634244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28634244 | http://www.w3.org/2000/01/rdf-schema#comment | "Eggshell patterning has been extensively studied in Drosophila melanogaster However, the cis-regulatory modules (CRMs), which control spatiotemporal expression of these patterns, are vastly unexplored. The FlyLight collection contains >7000 intergenic and intronic DNA fragments that, if containing CRMs, can drive the transcription factor GAL4. We cross-listed the 84 genes known to be expressed during D. melanogaster oogenesis with the ∼1200 listed genes of the FlyLight collection, and found 22 common genes that are represented by 281 FlyLight fly lines. Of these lines, 54 show expression patterns during oogenesis when crossed to an UAS-GFP reporter. Of the 54 lines, 16 recapitulate the full or partial pattern of the associated gene pattern. Interestingly, while the average DNA fragment size is ∼3 kb in length, the vast majority of fragments show one type of spatiotemporal pattern in oogenesis. Mapping the distribution of all 54 lines, we found a significant enrichment of CRMs in the first intron of the associated genes' model. In addition, we demonstrate the use of different anteriorly active FlyLight lines as tools to disrupt eggshell patterning in a targeted manner. Our screen provides further evidence that complex gene patterns are assembled combinatorially by different CRMs controlling the expression of genes in simple domains."xsd:string |
| http://purl.uniprot.org/citations/28634244 | http://purl.org/dc/terms/identifier | "doi:10.1534/g3.117.043810"xsd:string |
| http://purl.uniprot.org/citations/28634244 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/28634244 | http://purl.uniprot.org/core/author | "Farhat M."xsd:string |
| http://purl.uniprot.org/citations/28634244 | http://purl.uniprot.org/core/author | "Yakoby N."xsd:string |
| http://purl.uniprot.org/citations/28634244 | http://purl.uniprot.org/core/author | "Marmion R.A."xsd:string |
| http://purl.uniprot.org/citations/28634244 | http://purl.uniprot.org/core/author | "Ekiz V."xsd:string |
| http://purl.uniprot.org/citations/28634244 | http://purl.uniprot.org/core/author | "Revaitis N.T."xsd:string |
| http://purl.uniprot.org/citations/28634244 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28634244 | http://purl.uniprot.org/core/name | "G3 (Bethesda)"xsd:string |
| http://purl.uniprot.org/citations/28634244 | http://purl.uniprot.org/core/pages | "2705-2718"xsd:string |
| http://purl.uniprot.org/citations/28634244 | http://purl.uniprot.org/core/title | "Simple Expression Domains Are Regulated by Discrete CRMs During Drosophila Oogenesis."xsd:string |
| http://purl.uniprot.org/citations/28634244 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/28634244 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28634244 |
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