| http://purl.uniprot.org/citations/28637651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28637651 | http://www.w3.org/2000/01/rdf-schema#comment | "Adipose tissues considerably influence metabolic homeostasis, and both white (WAT) and brown (BAT) adipose tissue play significant roles in lipid and glucose metabolism. O-linked N-acetylglucosamine (O-GlcNAc) modification is characterized by the addition of N-acetylglucosamine to various proteins by O-GlcNAc transferase (Ogt), subsequently modulating various cellular processes. However, little is known about the role of O-GlcNAc modification in adipose tissues. Here, we report the critical role of O-GlcNAc modification in cold-induced thermogenesis. Deletion of Ogt in WAT and BAT using adiponectin promoter-driven Cre recombinase resulted in severe cold intolerance with decreased uncoupling protein 1 (Ucp1) expression. Furthermore, Ogt deletion led to decreased mitochondrial protein expression in conjunction with decreased peroxisome proliferator-activated receptor γ coactivator 1-α protein expression. This phenotype was further confirmed by deletion of Ogt in BAT using Ucp1 promoter-driven Cre recombinase, suggesting that O-GlcNAc modification in BAT is responsible for cold-induced thermogenesis. Hypothermia was significant under fasting conditions. This effect was mitigated after normal diet consumption but not after consumption of a fatty acid-rich ketogenic diet lacking carbohydrates, suggesting impaired diet-induced thermogenesis, particularly by fat. In conclusion, O-GlcNAc modification is essential for cold-induced thermogenesis and mitochondrial biogenesis in BAT. Glucose flux into BAT may be a signal to maintain BAT physiological responses."xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://purl.org/dc/terms/identifier | "doi:10.2337/db16-1427"xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://purl.uniprot.org/core/author | "Park S.Y."xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://purl.uniprot.org/core/author | "Ohashi N."xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://purl.uniprot.org/core/author | "Choi C.S."xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://purl.uniprot.org/core/author | "Morino K."xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://purl.uniprot.org/core/author | "Ida S."xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://purl.uniprot.org/core/author | "Maegawa H."xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://purl.uniprot.org/core/author | "Kume S."xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://purl.uniprot.org/core/author | "Ugi S."xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://purl.uniprot.org/core/author | "Sekine O."xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://purl.uniprot.org/core/author | "Lemecha M."xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28637651 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://purl.uniprot.org/core/pages | "2351-2362"xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://purl.uniprot.org/core/title | "Pivotal Role of O-GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis."xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://purl.uniprot.org/core/volume | "66"xsd:string |
| http://purl.uniprot.org/citations/28637651 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28637651 |
| http://purl.uniprot.org/citations/28637651 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28637651 |
| http://purl.uniprot.org/uniprot/P56558#attribution-71EE812076E4FDE2883FEE6DAC9B6040 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28637651 |
| http://purl.uniprot.org/uniprot/Q8CGY8#attribution-49F408D804F8623E8ECA39E1FC10415B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28637651 |
| http://purl.uniprot.org/uniprot/O15294#attribution-71EE812076E4FDE2883FEE6DAC9B6040 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28637651 |
| http://purl.uniprot.org/uniprot/A0A0G2K3V4#attribution-71EE812076E4FDE2883FEE6DAC9B6040 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28637651 |
| http://purl.uniprot.org/uniprot/G3V6F4#attribution-71EE812076E4FDE2883FEE6DAC9B6040 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/28637651 |