| http://purl.uniprot.org/citations/28641112 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28641112 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuroligins and neurexins promote synapse development and validation by forming trans-synaptic bridges spanning the synaptic cleft. Select pairs promote excitatory and inhibitory synapses, with neuroligin 2 (NLGN2) limited to inhibitory synapses and neuroligin 1 (NLGN1) dominating at excitatory synapses. The cell-surface molecules, MAM domain-containing glycosylphosphatidylinositol anchor 1 (MDGA1) and 2 (MDGA2), regulate trans-synaptic adhesion between neurexins and neuroligins, impacting NLGN2 and NLGN1, respectively. We have determined the molecular mechanism of MDGA action. MDGA1 Ig1-Ig2 is sufficient to bind NLGN2 with nanomolar affinity; its crystal structure reveals an unusual locked rod-shaped array. In the crystal structure of the complex, two MDGA1 Ig1-Ig2 molecules each span the entire NLGN2 dimer. Site-directed mutagenesis confirms the observed interaction interface. Strikingly, Ig1 from MDGA1 binds to the same region on NLGN2 as neurexins do. Thus, MDGAs regulate the formation of neuroligin-neurexin trans-synaptic bridges by sterically blocking access of neurexins to neuroligins."xsd:string |
| http://purl.uniprot.org/citations/28641112 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2017.06.009"xsd:string |
| http://purl.uniprot.org/citations/28641112 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/28641112 | http://purl.uniprot.org/core/author | "Zhong X."xsd:string |
| http://purl.uniprot.org/citations/28641112 | http://purl.uniprot.org/core/author | "Rudenko G."xsd:string |
| http://purl.uniprot.org/citations/28641112 | http://purl.uniprot.org/core/author | "Machius M."xsd:string |
| http://purl.uniprot.org/citations/28641112 | http://purl.uniprot.org/core/author | "Gangwar S.P."xsd:string |
| http://purl.uniprot.org/citations/28641112 | http://purl.uniprot.org/core/author | "Seshadrinathan S."xsd:string |
| http://purl.uniprot.org/citations/28641112 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28641112 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/28641112 | http://purl.uniprot.org/core/pages | "1132-1141.e4"xsd:string |
| http://purl.uniprot.org/citations/28641112 | http://purl.uniprot.org/core/title | "Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges."xsd:string |
| http://purl.uniprot.org/citations/28641112 | http://purl.uniprot.org/core/volume | "94"xsd:string |
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