| http://purl.uniprot.org/citations/28645154 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28645154 | http://www.w3.org/2000/01/rdf-schema#comment | "Caenorhabditis elegans contains 25 Argonautes, of which, ALG-1 and ALG-2 are known to primarily interact with miRNAs. ALG-5 belongs to the AGO subfamily of Argonautes that includes ALG-1 and ALG-2, but its role in small RNA pathways is unknown. We analyzed by high-throughput sequencing the small RNAs associated with ALG-5, ALG-1 and ALG-2, as well as changes in mRNA expression in alg-5, alg-1 and alg-2 mutants. We show that ALG-5 defines a distinct branch of the miRNA pathway affecting the expression of genes involved in immunity, defense, and development. In contrast to ALG-1 and ALG-2, which associate with most miRNAs and have general roles throughout development, ALG-5 interacts with only a small subset of miRNAs and is specifically expressed in the germline where it localizes alongside the piRNA and siRNA machinery at P granules. alg-5 is required for optimal fertility and mutations in alg-5 lead to a precocious transition from spermatogenesis to oogenesis. Our results provide a near-comprehensive analysis of miRNA-Argonaute interactions in C. elegans and reveal a new role for miRNAs in the germline."xsd:string |
| http://purl.uniprot.org/citations/28645154 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkx536"xsd:string |
| http://purl.uniprot.org/citations/28645154 | http://purl.uniprot.org/core/author | "Brown K.C."xsd:string |
| http://purl.uniprot.org/citations/28645154 | http://purl.uniprot.org/core/author | "Montgomery T.A."xsd:string |
| http://purl.uniprot.org/citations/28645154 | http://purl.uniprot.org/core/author | "Svendsen J.M."xsd:string |
| http://purl.uniprot.org/citations/28645154 | http://purl.uniprot.org/core/author | "Montgomery B.E."xsd:string |
| http://purl.uniprot.org/citations/28645154 | http://purl.uniprot.org/core/author | "Tucci R.M."xsd:string |
| http://purl.uniprot.org/citations/28645154 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28645154 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/28645154 | http://purl.uniprot.org/core/pages | "9093-9107"xsd:string |
| http://purl.uniprot.org/citations/28645154 | http://purl.uniprot.org/core/title | "ALG-5 is a miRNA-associated Argonaute required for proper developmental timing in the Caenorhabditis elegans germline."xsd:string |
| http://purl.uniprot.org/citations/28645154 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/28645154 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28645154 |
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