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http://purl.uniprot.org/citations/28646244http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Purpose

As life expectancy in cystic fibrosis (CF) increases, questions regarding its potential impact on cardiovascular health arise. Soluble vascular cell adhesion molecule 1 (sVCAM-1), P-selectin (sP-selectin) are proposed as biomarkers of cardiovascular disease. We aimed to: compare their concentrations in clinically stable CF patients and healthy subjects (HS) and verify whether they independently correlate with CF characteristics.

Methods

Serum sVCAM-1 and sP-selectin levels were measured using ELISA. CF was characterized using: forced expiratory volume in 1 s, exocrine pancreatic and CF-related liver disease status, Pseudomonas aeruginosa colonization, serum high-sensitivity C-reactive protein, and body mass index (BMI). CFTR genotypes were classified as severe (classes I and II) or other.

Results

108 CF patients and 51 healthy subjects volunteered for the study. In the CF group BMI was lower (median [IQR]: 20.5 kg/m2 [18.4-22.2] vs. 21.6 kg/m2 [19.9-23.4], p = 0.02) and hsCRP levels were higher (3.6 mg/L [1.1-7.1] vs. 0.5 mg/dL [0.3-1.0], p < 10-10). While sVCAM-1 concentrations were greater in CF patients (1018 ng/mL [851-1279] vs. 861 ng/mL [806-979], p < 10-4), sP-selectin levels did not differ (155 ng/mL [129-188] vs. 156 ng/mL [144-177], p = 0.48). None of the multivariable regression models was valid for the prediction of sVCAM-1 and sP-selectin in CF.

Conclusions

We found higher sVCAM-1 concentrations in CF patients than in healthy subjects, which were not explained by CF characteristics. Further research is required to check whether sVCAM-1 is a marker of microangiopathy in CF."xsd:string
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http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/author"Nowak J.K."xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/author"Szczepanik M."xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/author"Lisowska A."xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/author"Nowicka A."xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/author"Pogorzelski A."xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/author"Wojsyk-Banaszak I."xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/author"Walkowiak J."xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/author"Sapiejka E."xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/author"Krzyzanowska P."xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/author"Madry E."xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/author"Wykretowicz A."xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/author"Drzymala-Czyz S."xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/author"Skorupa W."xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/date"2017"xsd:gYear
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/name"Lung"xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/pages"445-453"xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/title"Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study."xsd:string
http://purl.uniprot.org/citations/28646244http://purl.uniprot.org/core/volume"195"xsd:string
http://purl.uniprot.org/citations/28646244http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/28646244
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