| http://purl.uniprot.org/citations/28649985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28649985 | http://www.w3.org/2000/01/rdf-schema#comment | "Most BRCA1-associated breast tumours are basal-like yet originate from luminal progenitors. BRCA1 is best known for its functions in double-strand break repair and resolution of DNA replication stress. However, it is unclear whether loss of these ubiquitously important functions fully explains the cell lineage-specific tumorigenesis. In vitro studies implicate BRCA1 in elimination of R-loops, DNA-RNA hybrid structures involved in transcription and genetic instability. Here we show that R-loops accumulate preferentially in breast luminal epithelial cells, not in basal epithelial or stromal cells, of BRCA1 mutation carriers. Furthermore, R-loops are enriched at the 5' end of those genes with promoter-proximal RNA polymerase II (Pol II) pausing. Genetic ablation of Cobra1, which encodes a Pol II-pausing and BRCA1-binding protein, ameliorates R-loop accumulation and reduces tumorigenesis in Brca1-knockout mouse mammary epithelium. Our studies show that Pol II pausing is an important contributor to BRCA1-associated R-loop accumulation and breast cancer development."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms15908"xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Li R."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Smith S."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Chedin F."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Chiang H.C."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Michalek J."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Sun L.Z."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Petit A."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Brunet J."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Oliver B."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Soler T."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Isaacs C."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Nair S.J."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Jin V.X."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Lautner M."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Curiel T.J."xsd:string |
| http://purl.uniprot.org/citations/28649985 | http://purl.uniprot.org/core/author | "Peshkin B.N."xsd:string |