| http://purl.uniprot.org/citations/28652322 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28652322 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA-dependent protein kinase (DNA-PK) is a large protein complex central to the nonhomologous end joining (NHEJ) DNA-repair pathway. It comprises the DNA-PK catalytic subunit (DNA-PKcs) and the heterodimer of DNA-binding proteins Ku70 and Ku80. Here, we report the cryo-electron microscopy (cryo-EM) structures of human DNA-PKcs at 4.4-Å resolution and the DNA-PK holoenzyme at 5.8-Å resolution. The DNA-PKcs structure contains three distinct segments: the N-terminal region with an arm and a bridge, the circular cradle, and the head that includes the kinase domain. Two perpendicular apertures exist in the structure, which are sufficiently large for the passage of dsDNA. The DNA-PK holoenzyme cryo-EM map reveals density for the C-terminal globular domain of Ku80 that interacts with the arm of DNA-PKcs. The Ku80-binding site is adjacent to the previously identified density for the DNA-binding region of the Ku70/Ku80 complex, suggesting concerted DNA interaction by DNA-PKcs and the Ku complex."xsd:string |
| http://purl.uniprot.org/citations/28652322 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1707386114"xsd:string |
| http://purl.uniprot.org/citations/28652322 | http://purl.uniprot.org/core/author | "Dong L."xsd:string |
| http://purl.uniprot.org/citations/28652322 | http://purl.uniprot.org/core/author | "Dong Y."xsd:string |
| http://purl.uniprot.org/citations/28652322 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/28652322 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/28652322 | http://purl.uniprot.org/core/author | "Mao Y."xsd:string |
| http://purl.uniprot.org/citations/28652322 | http://purl.uniprot.org/core/author | "Wang W.L."xsd:string |
| http://purl.uniprot.org/citations/28652322 | http://purl.uniprot.org/core/author | "Sharif H."xsd:string |
| http://purl.uniprot.org/citations/28652322 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28652322 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/28652322 | http://purl.uniprot.org/core/pages | "7367-7372"xsd:string |
| http://purl.uniprot.org/citations/28652322 | http://purl.uniprot.org/core/title | "Cryo-EM structure of the DNA-PK holoenzyme."xsd:string |
| http://purl.uniprot.org/citations/28652322 | http://purl.uniprot.org/core/volume | "114"xsd:string |
| http://purl.uniprot.org/citations/28652322 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/28652322 |
| http://purl.uniprot.org/citations/28652322 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/28652322 |
| http://purl.uniprot.org/uniprot/#_B4DL41-mappedCitation-28652322 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28652322 |
| http://purl.uniprot.org/uniprot/#_P78527-mappedCitation-28652322 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/28652322 |
| http://purl.uniprot.org/uniprot/P78527 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28652322 |
| http://purl.uniprot.org/uniprot/B4DL41 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/28652322 |