| http://purl.uniprot.org/citations/28658624 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/28658624 | http://www.w3.org/2000/01/rdf-schema#comment | "Energetic nutrients are oxidized to sustain high intracellular NADPH/NADP+ ratios. NADPH-dependent reduction of thioredoxin-1 (Trx1) disulfide and glutathione disulfide by thioredoxin reductase-1 (TrxR1) and glutathione reductase (Gsr), respectively, fuels antioxidant systems and deoxyribonucleotide synthesis. Mouse livers lacking both TrxR1 and Gsr sustain these essential activities using an NADPH-independent methionine-consuming pathway; however, it remains unclear how this reducing power is distributed. Here, we show that liver-specific co-disruption of the genes encoding Trx1, TrxR1, and Gsr (triple-null) causes dramatic hepatocyte hyperproliferation. Thus, even in the absence of Trx1, methionine-fueled glutathione production supports hepatocyte S phase deoxyribonucleotide production. Also, Trx1 in the absence of TrxR1 provides a survival advantage to cells under hyperglycemic stress, suggesting that glutathione, likely via glutaredoxins, can reduce Trx1 disulfide in vivo. In triple-null livers like in many cancers, deoxyribonucleotide synthesis places a critical yet relatively low-volume demand on these reductase systems, thereby favoring high hepatocyte turnover over sustained hepatocyte integrity."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2017.06.019"xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Schmidt E.E."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Holmgren A."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Miller C.G."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Ogata F."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Orlicky D.J."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Taylor M.P."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Prigge J.R."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Martin S.S."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Arner E.S.J."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Shearn C.T."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Mattsson A."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Kundert J.A."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Gustafsson T.N."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Coppo L."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Bruschwein M.D."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Herr A.E."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/author | "Lytchier J."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/date | "2017"xsd:gYear |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/pages | "2771-2781"xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/title | "Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase."xsd:string |
| http://purl.uniprot.org/citations/28658624 | http://purl.uniprot.org/core/volume | "19"xsd:string |